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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F08%3A00002550%21RIV10-MSM-16370___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals. S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals.
dcterms:title
Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu
skos:prefLabel
Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu
skos:notation
RIV/62157124:16370/08:00002550!RIV10-MSM-16370___
n5:aktivita
n17:V
n5:aktivity
V
n5:cisloPeriodika
Suppl.1
n5:dodaniDat
n10:2010
n5:domaciTvurceVysledku
n6:9312579 n6:3764419 n6:7985479 n6:9818545 n6:5062926 n6:5540305 n6:9201041
n5:druhVysledku
n15:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n8:predkladatel
n5:idSjednocenehoVysledku
365258
n5:idVysledku
RIV/62157124:16370/08:00002550
n5:jazykVysledku
n12:eng
n5:klicovaSlova
Stereoisomery; Aryloxyaminopropanols
n5:klicoveSlovo
n11:Stereoisomery n11:Aryloxyaminopropanols
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[8E1AC21ED3E3]
n5:nazevZdroje
Prague Medical Report
n5:obor
n13:FR
n5:pocetDomacichTvurcuVysledku
7
n5:pocetTvurcuVysledku
10
n5:rokUplatneniVysledku
n10:2008
n5:svazekPeriodika
109
n5:tvurceVysledku
Opatřilová, Radka Brunclík, Vít Beránková, Klára Suchý, Pavel Parák, Tomáš Bartošová, Ladislava Součková, Irena Mokrý, Petr Frydrych, Marek Kolevská, Jana
s:issn
1214-6994
s:numberOfPages
4
n14:organizacniJednotka
16370