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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F03%3A00000015%21RIV%2F2004%2FMSM%2F163704%2FN
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The influence of the newly developed ultrashort acting beta-adrenergic blockers on the heart rate was measured on laboratory male Wistar rats with normal blood pressure. Three tested compounds were injected intravenously under general anaesthesia into the animals. At specific time intervals, the heart rate in all animals was measured from a record of their ECG. These results were converted into the percentages of perturbations of the heart rate. All evaluated compounds have shown a significant verifiable short-term bradycardic effect on the heart rate. The most significant reduction was observed in the first few minutes after i.v. administration. The influence of the newly developed ultrashort acting beta-adrenergic blockers on the heart rate was measured on laboratory male Wistar rats with normal blood pressure. Three tested compounds were injected intravenously under general anaesthesia into the animals. At specific time intervals, the heart rate in all animals was measured from a record of their ECG. These results were converted into the percentages of perturbations of the heart rate. All evaluated compounds have shown a significant verifiable short-term bradycardic effect on the heart rate. The most significant reduction was observed in the first few minutes after i.v. administration.
dcterms:title
Changes in heart rate after application of newly developed ultrashort acting beta-adrenergic blockers. Changes in heart rate after application of newly developed ultrashort acting beta-adrenergic blockers.
skos:prefLabel
Changes in heart rate after application of newly developed ultrashort acting beta-adrenergic blockers. Changes in heart rate after application of newly developed ultrashort acting beta-adrenergic blockers.
skos:notation
RIV/62157124:16370/03:00000015!RIV/2004/MSM/163704/N
n3:strany
841-842
n3:aktivita
n13:Z
n3:aktivity
Z(MSM 161700002), Z(MSM 163700003)
n3:cisloPeriodika
4
n3:dodaniDat
n4:2004
n3:domaciTvurceVysledku
n7:9818545 n7:4203860 n7:9312579 n7:7985479
n3:druhVysledku
n9:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
600833
n3:idVysledku
RIV/62157124:16370/03:00000015
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Laboratory rat, ultrashort acting beta-blockers, heart rate, ECG changes
n3:klicoveSlovo
n6:ECG%20changes n6:ultrashort%20acting%20beta-blockers n6:heart%20rate n6:Laboratory%20rat
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[CABB2F1433DA]
n3:nazevZdroje
Pharmazie
n3:obor
n16:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n4:2003
n3:svazekPeriodika
58
n3:tvurceVysledku
Brunclík, Vít Frydrych, Marek Bartošová, Ladislava Kotolová, Hana Mokrý, Petr
n3:zamer
n8:MSM%20161700002 n8:MSM%20163700003
s:issn
0031-7144
s:numberOfPages
2
n12:organizacniJednotka
16370