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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F13%3A43872363%21RIV14-MSM-16270___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
OBJECTIVES: Toxic effects of the yew have been known since ancient times. Yew toxicity is due to the content of cyanogenic glycosides and a mixture of alkaloids known as taxines. Taxine B is probably responsible for the most part of adverse effects in poisoned organisms. This particular taxoid is common in body fluids of the yew-poisoned. The present study is engaged with laboratory examination to confirm substances that lead to fatality of a pair of olive baboons (Papio anubis) following ingestion of yew seeds. When both cage mates (male and female) died suddenly, poisoning was suspected because many berries had fallen into the cage from a nearby fruiting yew tree (Taxus baccata) during the windy night before. METHODS: The analysis was performed using electrospray ionization quadrupole time-of-flight mass spectrometry. A flow injection analysis/mass spectrometry setting was prepared for this purpose. RESULTS: The above mentioned mass spectrometry analysis of taxoids confirmed poisoning by taxanes. The presence of taxin B/isotaxin B was confirmed in all investigated samples. Apparently in urine and bile there were concentrations ranging 150-220 ng.mL-1 and in blood serum concentrations 25-30 ng.mL-1. CONCLUSION: It follows from the results obtained that we confirmed that baboons were deadly intoxicated by yew fruits. OBJECTIVES: Toxic effects of the yew have been known since ancient times. Yew toxicity is due to the content of cyanogenic glycosides and a mixture of alkaloids known as taxines. Taxine B is probably responsible for the most part of adverse effects in poisoned organisms. This particular taxoid is common in body fluids of the yew-poisoned. The present study is engaged with laboratory examination to confirm substances that lead to fatality of a pair of olive baboons (Papio anubis) following ingestion of yew seeds. When both cage mates (male and female) died suddenly, poisoning was suspected because many berries had fallen into the cage from a nearby fruiting yew tree (Taxus baccata) during the windy night before. METHODS: The analysis was performed using electrospray ionization quadrupole time-of-flight mass spectrometry. A flow injection analysis/mass spectrometry setting was prepared for this purpose. RESULTS: The above mentioned mass spectrometry analysis of taxoids confirmed poisoning by taxanes. The presence of taxin B/isotaxin B was confirmed in all investigated samples. Apparently in urine and bile there were concentrations ranging 150-220 ng.mL-1 and in blood serum concentrations 25-30 ng.mL-1. CONCLUSION: It follows from the results obtained that we confirmed that baboons were deadly intoxicated by yew fruits.
dcterms:title
Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis
skos:prefLabel
Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis
skos:notation
RIV/62157124:16270/13:43872363!RIV14-MSM-16270___
n11:predkladatel
n15:orjk%3A16270
n3:aktivita
n18:Z
n3:aktivity
Z(MSM6215712402)
n3:cisloPeriodika
Suppl. 2
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n8:9847065 n8:6786294 n8:7957092 n8:4771079 n8:8740658 n8:1936468
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
117643
n3:idVysledku
RIV/62157124:16270/13:43872363
n3:jazykVysledku
n5:eng
n3:klicovaSlova
taxoids; Taxus baccata; European yew; fatality; Zoo animals
n3:klicoveSlovo
n4:European%20yew n4:fatality n4:Zoo%20animals n4:taxoids n4:Taxus%20baccata
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[16CDEE275105]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
34
n3:tvurceVysledku
Komínková, Markéta Sedláčková, Jana Banďouchová, Hana Beklová, Miroslava Pikula, Jiří Mazánek, Stanislav Zítka, Ondřej Stanisavljevic, Maja Kizek, Rene
n3:wos
000330901000020
n3:zamer
n13:MSM6215712402
s:issn
0172-780X
s:numberOfPages
4
n16:organizacniJednotka
16270