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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F13%3A43872269%21RIV14-MSM-16270___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Tacrine is an inhibitor of acetylcholinestrase (AChE) formerly used to treat cognitive impairment of Alzheimer disease. In previous works, we have shown that inhibitors of AChE can modulate innate immunity responses. In the present study we focused on modulation of adaptive immunity represented by production of antibodies. It is hypothesized that the cholinergic anti-inflammatory pathway is a common mechanism how inhibitors of AChE can influence immunity. Here, tularemia is used as a model disease for experimental purposes. Tacrine significantly suppressed adaptive immunity represented by the ability of the organism to produce antibodies. We infer that tacrine can modulate the cholinergic anti-inflammatory pathway by a mechanism based on inhibition of blood AChE followed by higher availability of acetylcholine. The anti-inflammatory pathway is then stimulated and the body is not able to simply resolve antigen. Application of an AChE inhibitor during infectious diseases can have detrimental consequences for the immune system. Tacrine is an inhibitor of acetylcholinestrase (AChE) formerly used to treat cognitive impairment of Alzheimer disease. In previous works, we have shown that inhibitors of AChE can modulate innate immunity responses. In the present study we focused on modulation of adaptive immunity represented by production of antibodies. It is hypothesized that the cholinergic anti-inflammatory pathway is a common mechanism how inhibitors of AChE can influence immunity. Here, tularemia is used as a model disease for experimental purposes. Tacrine significantly suppressed adaptive immunity represented by the ability of the organism to produce antibodies. We infer that tacrine can modulate the cholinergic anti-inflammatory pathway by a mechanism based on inhibition of blood AChE followed by higher availability of acetylcholine. The anti-inflammatory pathway is then stimulated and the body is not able to simply resolve antigen. Application of an AChE inhibitor during infectious diseases can have detrimental consequences for the immune system.
dcterms:title
Tacrine alters antibodies level in Francisella tularensis-infected mice Tacrine alters antibodies level in Francisella tularensis-infected mice
skos:prefLabel
Tacrine alters antibodies level in Francisella tularensis-infected mice Tacrine alters antibodies level in Francisella tularensis-infected mice
skos:notation
RIV/62157124:16270/13:43872269!RIV14-MSM-16270___
n11:predkladatel
n12:orjk%3A16270
n4:aktivita
n14:I n14:P
n4:aktivity
I, P(LH11023)
n4:cisloPeriodika
Suppl. 2
n4:dodaniDat
n13:2014
n4:domaciTvurceVysledku
n15:9847065
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
109753
n4:idVysledku
RIV/62157124:16270/13:43872269
n4:jazykVysledku
n19:eng
n4:klicovaSlova
Alzheimer disease; neuroimmunology; Francisella tularensis; immune reactivity; acetylcholinesterase
n4:klicoveSlovo
n8:Alzheimer%20disease n8:acetylcholinesterase n8:neuroimmunology n8:immune%20reactivity n8:Francisella%20tularensis
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[662A973C2041]
n4:nazevZdroje
Neuroendocrinology Letters
n4:obor
n7:GJ
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
3
n4:projekt
n9:LH11023
n4:rokUplatneniVysledku
n13:2013
n4:svazekPeriodika
34
n4:tvurceVysledku
Pikula, Jiří Pavliš, Oto Pohanka, Miroslav
n4:wos
000330901000021
s:issn
0172-780X
s:numberOfPages
4
n18:organizacniJednotka
16270