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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F12%3A43871479%21RIV13-MSM-16270___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Pharmaceuticals and heavy metals have been identified as environmental contaminants toxic to birds and posing serious threats to declining populations of raptors worldwide. The aim of the present study was to test the hypothesis that a sublethal combination of NSAIDs and lead induces more pronounced effects than single exposures in birds. A total of 40 Japanese quails at the age of 2 months and average weight of 180g were on a random basis divided into four experimental groups of 10 specimens. Six lead shots in the total weight of 1.5 grams were inserted into the crop on day 0 of the experiment, while a total of 5 mg/kg of diclofenac administered intramuscularly were divided into treatments on days 0 and 5. Group responses were compared using haematology and biochemistry after 10 days. There was no mortality in control and both single and combined diclofenac and lead exposure groups, nor did the birds show any clinical signs of intoxication. Univariate analyses of blood parameters yielded a decrease in haematocrit in birds exposed to both substances when compared with the control, a lower haemoglobin level of the lead-exposed group, increased activity of aspartate aminotransferase in the NSAIDs-exposed group, increased activity of alkaline phosphatase in birds exposed to a combination of diclofenac and lead, and a higher phosphorus level in the lead-exposed group. The principal component analysis revealed no multivariate pattern of responses of blood parameters and did not allow separation of exposure groups from controls when the variables and samples were projected onto a two dimensional space. Results of the present study can enhance understanding of combination toxicity of veterinary drugs and heavy metals in birds. Fortunately, individual blood parameter effects prevailed and no joint mortal effects were recognised in Japanese quails exposed to a combination of sublethal doses of diclofenac and lead. Pharmaceuticals and heavy metals have been identified as environmental contaminants toxic to birds and posing serious threats to declining populations of raptors worldwide. The aim of the present study was to test the hypothesis that a sublethal combination of NSAIDs and lead induces more pronounced effects than single exposures in birds. A total of 40 Japanese quails at the age of 2 months and average weight of 180g were on a random basis divided into four experimental groups of 10 specimens. Six lead shots in the total weight of 1.5 grams were inserted into the crop on day 0 of the experiment, while a total of 5 mg/kg of diclofenac administered intramuscularly were divided into treatments on days 0 and 5. Group responses were compared using haematology and biochemistry after 10 days. There was no mortality in control and both single and combined diclofenac and lead exposure groups, nor did the birds show any clinical signs of intoxication. Univariate analyses of blood parameters yielded a decrease in haematocrit in birds exposed to both substances when compared with the control, a lower haemoglobin level of the lead-exposed group, increased activity of aspartate aminotransferase in the NSAIDs-exposed group, increased activity of alkaline phosphatase in birds exposed to a combination of diclofenac and lead, and a higher phosphorus level in the lead-exposed group. The principal component analysis revealed no multivariate pattern of responses of blood parameters and did not allow separation of exposure groups from controls when the variables and samples were projected onto a two dimensional space. Results of the present study can enhance understanding of combination toxicity of veterinary drugs and heavy metals in birds. Fortunately, individual blood parameter effects prevailed and no joint mortal effects were recognised in Japanese quails exposed to a combination of sublethal doses of diclofenac and lead.
dcterms:title
Risk of single and combined exposure of birds to non-steroidal anti-inflammatory drugs and lead Risk of single and combined exposure of birds to non-steroidal anti-inflammatory drugs and lead
skos:prefLabel
Risk of single and combined exposure of birds to non-steroidal anti-inflammatory drugs and lead Risk of single and combined exposure of birds to non-steroidal anti-inflammatory drugs and lead
skos:notation
RIV/62157124:16270/12:43871479!RIV13-MSM-16270___
n16:predkladatel
n17:orjk%3A16270
n3:aktivita
n9:V n9:S
n3:aktivity
S, V
n3:cisloPeriodika
suppl. 3
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n8:6786294 n8:7003064 n8:7735898 n8:1820303 n8:6650066 n8:2546795 n8:4675401 n8:9847065 n8:6386792
n3:druhVysledku
n13:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
165686
n3:idVysledku
RIV/62157124:16270/12:43871479
n3:jazykVysledku
n15:eng
n3:klicovaSlova
birds; biochemistry; haematology; diclofenac; heavy metals
n3:klicoveSlovo
n4:haematology n4:biochemistry n4:birds n4:heavy%20metals n4:diclofenac
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[438ED1FC0F6F]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n12:GJ
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Škochová, Hana Král, Jiří Ondráček, Karel Pohanka, Miroslav Pikula, Jiří Banďouchová, Hana Osičková, Jitka Pecková, Lucie Damková, Veronika Vitula, František
s:issn
0172-780X
s:numberOfPages
6
n18:organizacniJednotka
16270