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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F12%3A43871458%21RIV13-MSM-16270___
rdf:type
skos:Concept n3:Vysledek
dcterms:description
Huperzine is a secondary metabolite in lycopods Huprzia and an inhibitor of acetylcholinesterase and antagonist of N-methyl-D-apartate receptor. Huperine is a suitable drug for the treatment of Alzheimer's disease as it is a part of traditional Chinese medicine. Currently, it undergoes clinical trials in the European Union and United States. The toxicological data about huperzine are missing and link between huperzine and oxidative stress has not been extensively investigated. For the above mentioned reasons, we organized experiment on a guinea pig model aimed at the investigation of adverse effects caused by huperzine. Guinea pigs were exposed to (-)-huperzine A in doses 5-625 mu g/kg. Animals were sacrificed one day after exposure. Ferric reducing antioxidant power, thiobarbituric acid reactive substances, glutathione reductase, caspase 3 activity and selected biochemical markers (e. g. transaminases, blood urea nitrogen and glucose) were assayed. In frontal, parietal, temporal lobes and cerebellum, we found increase of antioxidants, glutathione reductase and oxidative stress markers in a dose dependent manner. Effects on liver, kidney and spleen were milder. We discuss ambivalent action of huperzine in the body and judge the huperzine action owing to recently reported experiments. Huperzine is a secondary metabolite in lycopods Huprzia and an inhibitor of acetylcholinesterase and antagonist of N-methyl-D-apartate receptor. Huperine is a suitable drug for the treatment of Alzheimer's disease as it is a part of traditional Chinese medicine. Currently, it undergoes clinical trials in the European Union and United States. The toxicological data about huperzine are missing and link between huperzine and oxidative stress has not been extensively investigated. For the above mentioned reasons, we organized experiment on a guinea pig model aimed at the investigation of adverse effects caused by huperzine. Guinea pigs were exposed to (-)-huperzine A in doses 5-625 mu g/kg. Animals were sacrificed one day after exposure. Ferric reducing antioxidant power, thiobarbituric acid reactive substances, glutathione reductase, caspase 3 activity and selected biochemical markers (e. g. transaminases, blood urea nitrogen and glucose) were assayed. In frontal, parietal, temporal lobes and cerebellum, we found increase of antioxidants, glutathione reductase and oxidative stress markers in a dose dependent manner. Effects on liver, kidney and spleen were milder. We discuss ambivalent action of huperzine in the body and judge the huperzine action owing to recently reported experiments.
dcterms:title
Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model
skos:prefLabel
Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model
skos:notation
RIV/62157124:16270/12:43871458!RIV13-MSM-16270___
n3:predkladatel
n4:orjk%3A16270
n5:aktivita
n11:V n11:P
n5:aktivity
P(OVUVZU2008002), V
n5:cisloPeriodika
3
n5:dodaniDat
n7:2013
n5:domaciTvurceVysledku
n18:9847065 n18:6786294
n5:druhVysledku
n19:J
n5:duvernostUdaju
n10:S
n5:entitaPredkladatele
n13:predkladatel
n5:idSjednocenehoVysledku
174750
n5:idVysledku
RIV/62157124:16270/12:43871458
n5:jazykVysledku
n20:eng
n5:klicovaSlova
oxidative stress; NMDA receptor; acetylcholinesterase; Alzheimer's disease; Huperzine
n5:klicoveSlovo
n9:Huperzine n9:Alzheimer%27s%20disease n9:acetylcholinesterase n9:NMDA%20receptor n9:oxidative%20stress
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[B73BA633D0DF]
n5:nazevZdroje
Toxicology Mechanisms and Methods
n5:obor
n14:GJ
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
4
n5:projekt
n16:OVUVZU2008002
n5:rokUplatneniVysledku
n7:2012
n5:svazekPeriodika
22
n5:tvurceVysledku
Zemek, Filip Pikula, Jiří Banďouchová, Hana Pohanka, Miroslav
n5:wos
000300254700009
s:issn
1537-6516
s:numberOfPages
5
n15:doi
10.3109/15376516.2011.635320
n12:organizacniJednotka
16270