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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F12%3A43871455%21RIV13-MSM-16270___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Objective: Francisella tularensis is an intracellular pathogen causing tularemia disease. Immune system action against tularemia is limited due to lipopolysaccharide covering bacterial cell. Cholinergic anti-inflammatory pathway is a link between parasympathetic nervous system and macrophage assisted immunity. Asoxime (also known as HI-6) is a compound implicated in regulation of acetylcholinesterase as well as acetylcholine receptors. We hypothesize suitability of asoxime to modulate tularemia progression. Procedure and experiment design: Laboratory mice BALB/c were infected with F. tularensis LVS strain and challenged by application of 209 mu g/kg to 209 mg/kg of HI-6 in the experiment beginning and then the next day. Mice were sacrificed after five days. Plasma, spleen and liver were sampled. In the separate experiment, tularemia caused mortality was assessed with and without of asoxime application. Results and Conclusions: Regarding to oxidative damage of liver and spleen, asoxime altered lipid peroxidation in liver and significantly reduced oxidative damage in spleens. We also proved significant increase of plasmatic antibodies level, decrease of IL6 and steady level of IFN gamma. Mice treated with asoxime had reduced mortality when compared to the infected and untreated ones. The best protective index was calculated 2.6 for asoxime doses 2.09 and 20.9 mg/kg. Asoxime can be considered as a compound reducing detrimental impact of tularemia. Effect of asoxime on cholinergic anti-inflammatory pathway and overall practical effect is discussed. Objective: Francisella tularensis is an intracellular pathogen causing tularemia disease. Immune system action against tularemia is limited due to lipopolysaccharide covering bacterial cell. Cholinergic anti-inflammatory pathway is a link between parasympathetic nervous system and macrophage assisted immunity. Asoxime (also known as HI-6) is a compound implicated in regulation of acetylcholinesterase as well as acetylcholine receptors. We hypothesize suitability of asoxime to modulate tularemia progression. Procedure and experiment design: Laboratory mice BALB/c were infected with F. tularensis LVS strain and challenged by application of 209 mu g/kg to 209 mg/kg of HI-6 in the experiment beginning and then the next day. Mice were sacrificed after five days. Plasma, spleen and liver were sampled. In the separate experiment, tularemia caused mortality was assessed with and without of asoxime application. Results and Conclusions: Regarding to oxidative damage of liver and spleen, asoxime altered lipid peroxidation in liver and significantly reduced oxidative damage in spleens. We also proved significant increase of plasmatic antibodies level, decrease of IL6 and steady level of IFN gamma. Mice treated with asoxime had reduced mortality when compared to the infected and untreated ones. The best protective index was calculated 2.6 for asoxime doses 2.09 and 20.9 mg/kg. Asoxime can be considered as a compound reducing detrimental impact of tularemia. Effect of asoxime on cholinergic anti-inflammatory pathway and overall practical effect is discussed.
dcterms:title
Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6) Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6)
skos:prefLabel
Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6) Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6)
skos:notation
RIV/62157124:16270/12:43871455!RIV13-MSM-16270___
n13:predkladatel
n18:orjk%3A16270
n3:aktivita
n7:V n7:I
n3:aktivity
I, V
n3:cisloPeriodika
1
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n15:9847065
n3:druhVysledku
n16:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
175306
n3:idVysledku
RIV/62157124:16270/12:43871455
n3:jazykVysledku
n17:eng
n3:klicovaSlova
cholinergic anti-inflammatory pathway; oxidative stress; inflammation; HI-6; Francisella tularensis
n3:klicoveSlovo
n8:inflammation n8:Francisella%20tularensis n8:cholinergic%20anti-inflammatory%20pathway n8:oxidative%20stress n8:HI-6
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E8FA44892591]
n3:nazevZdroje
International journal of applied research in veterinary medicine
n3:obor
n12:GJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
10
n3:tvurceVysledku
Pikula, Jiří Pohanka, Miroslav Kuča, Kamil Pavlis, Oto
n3:wos
000302334100011
s:issn
1542-2666
s:numberOfPages
9
n11:organizacniJednotka
16270