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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F10%3A00002769%21RIV11-MSM-16270___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates. Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates.
dcterms:title
Use of Crustacean Artemia franciscana for Alternative Biotests Use of Crustacean Artemia franciscana for Alternative Biotests
skos:prefLabel
Use of Crustacean Artemia franciscana for Alternative Biotests Use of Crustacean Artemia franciscana for Alternative Biotests
skos:notation
RIV/62157124:16270/10:00002769!RIV11-MSM-16270___
n3:aktivita
n10:Z
n3:aktivity
Z(MSM6215712402)
n3:cisloPeriodika
9
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n12:4670094 n12:2556553
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
294659
n3:idVysledku
RIV/62157124:16270/10:00002769
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Artemia salina; Synergy effects; irradiation; pharmacotoxicology
n3:klicoveSlovo
n9:irradiation n9:pharmacotoxicology n9:Artemia%20salina n9:Synergy%20effects
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[A45CA73D77A5]
n3:nazevZdroje
Acta veterinaria Brno
n3:obor
n11:GM
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
79
n3:tvurceVysledku
Dvořák, Petr Beňová, Katarína Sklenář, Zbyněk Havelková, Alena Ždárský, Michal
n3:wos
000282195800008
n3:zamer
n16:MSM6215712402
s:issn
0001-7213
s:numberOfPages
7
n13:organizacniJednotka
16270