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Statements

Subject Item
n2:RIV%2F62157124%3A16270%2F06%3A00000966%21RIV07-MSM-16270___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
CÍLE: Xenoestrogenní potenciál propylparabenu, jednoho z nejpoužívanějších konzervantů v kosmetice, léčivech a potravinách, byl vyšetřován v testu na daniu pruhovaném (Danio rerio) METODIKA: Juvenilní dania pruhovaná (Danio rerio) ve věku 20 dnů po vylíhnutí byla exponována třem různým koncentracím propylparabenu rozpuštěného v ethanolu a přidaného do vody. Po 20 dnech expozice byly ryby utraceny a koncentrace vitellogeninu v homogenátech jejich těl byly měřeny pomocí přímé sendvičové ELISA metody. Zároveň byly měřeny koncentrace vitellogeninu v homogenátech těl kontrolních ryb a v homogenátech těl ryb ze skupiny pozitivní kontroly exponované přirozeným estrogenem 17&#946;-estradiolem. VÝSLEDKY: Koncentrace vitellogeninu v homogenátech těl kontrolních ryb byly 400 (396-540) ng/ml (geometrický průměr (95%CI)). Expozice danií propylparabenem v koncentracích 0,1; 0,4 a 0,9 mg/l vyvolala statisticky významný pokles (p<0,001) v produkci vitellogeninu u exponovaných ryb. Geometrické průměry koncent Brominated flame retardants (BFRs) are organic substances frequently used in many industries. The most important group within BFRs are polybrominated diphenyl ethers (PBDEs). Because they persist in the environment, get accumulated in food chains and have toxic effects, they are a potential health risk for both animals and man. Polybrominated diphenyl ethers may disrupt processes of hormonal regulation in living organisms by reducing thyroxine concentrations in the plasma of exposed individuals. In vitro studies have demonstrated the ability of these substances to bind to estrogen and androgen receptors. Tests on rodents have also demonstrated neurotoxicity of some of the PBDEs. Although industrial use of PBDEs is now regulated to a large extent, PBDEs have already been detected in areas with no apparent industrial load, e.g. in Greenland. This article presents an overview of BFRs-related issues with a particular emphasis on PBDEs, describes toxic effects of those substances and their metabolism in li Brominated flame retardants (BFRs) are organic substances frequently used in many industries. The most important group within BFRs are polybrominated diphenyl ethers (PBDEs). Because they persist in the environment, get accumulated in food chains and have toxic effects, they are a potential health risk for both animals and man. Polybrominated diphenyl ethers may disrupt processes of hormonal regulation in living organisms by reducing thyroxine concentrations in the plasma of exposed individuals. In vitro studies have demonstrated the ability of these substances to bind to estrogen and androgen receptors. Tests on rodents have also demonstrated neurotoxicity of some of the PBDEs. Although industrial use of PBDEs is now regulated to a large extent, PBDEs have already been detected in areas with no apparent industrial load, e.g. in Greenland. This article presents an overview of BFRs-related issues with a particular emphasis on PBDEs, describes toxic effects of those substances and their metabolism in li
dcterms:title
Brominated flame retardants in the environment: their sources and effects (review). Brominated flame retardants in the environment: their sources and effects (review). Hodnocení xenoestrogenního potenciálu propylparabenu u dania pruhovaného (D. rerio).
skos:prefLabel
Brominated flame retardants in the environment: their sources and effects (review). Brominated flame retardants in the environment: their sources and effects (review). Hodnocení xenoestrogenního potenciálu propylparabenu u dania pruhovaného (D. rerio).
skos:notation
RIV/62157124:16270/06:00000966!RIV07-MSM-16270___
n4:strany
104-107
n4:aktivita
n14:Z
n4:aktivity
Z(MSM6215712402)
n4:cisloPeriodika
N
n4:dodaniDat
n5:2007
n4:domaciTvurceVysledku
n12:2017873 n12:1253379
n4:druhVysledku
n17:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
467420
n4:idVysledku
RIV/62157124:16270/06:00000966
n4:jazykVysledku
n7:eng
n4:klicovaSlova
BFRs; polybrominated diphenyl ethers; tetrabromobisphenol A; environmental endocrine disruptors; toxicity; metabolism
n4:klicoveSlovo
n6:BFRs n6:metabolism n6:polybrominated%20diphenyl%20ethers n6:environmental%20endocrine%20disruptors n6:toxicity n6:tetrabromobisphenol%20A
n4:kodStatuVydavatele
SE - Švédské království
n4:kontrolniKodProRIV
[A9FF072EFB2E]
n4:nazevZdroje
Neuroendocrinology Letters
n4:obor
n11:GJ
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n5:2006
n4:svazekPeriodika
27
n4:tvurceVysledku
Mikula, Přemysl Svobodová, Zdeňka Jarkovský, Jiří Dobšíková, Radka
n4:zamer
n18:MSM6215712402
s:issn
0172-780X
s:numberOfPages
4
n13:organizacniJednotka
16270