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Statements

Subject Item
n2:RIV%2F62157124%3A16170%2F14%3A43873327%21RIV15-MSM-16170___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Among activation of apoptotic machinery, Fas (CD95)/FasL (CD178) were suggested to act in cell proliferation and differentiation. Expression of Fas and FasL was reported during tooth and bone formation. The examination of gld mice showed increased total body bone mass and number of osteoblasts in long bones. However, Fas and FasL functions in osteogenesis remain controversial. As most of studies dealing with Fas/FasL system in bone formation were performed in endochondral models, we turned to intramembranous bones. The aim of our study was to investigate functions of FasL in development of the mandibular and alveolar bones using immunohistochemistry and impact of FasL deficiency by microCT examination of gld mice. This project continues our earlier published investigations of Fas/FasL in prenatal molar tooth development. Heads at embryonic (E) 12.5, 15.5, 17.5 and postnatal (P) 0, 1, 4, 11 days were used for immunohistochemical analysis. FasL was localized in the dental epithelium, dental follicle and a few cells of the dental papilla. In general, as the tooth development progressed, FasL expression decreased. Notably, similar pattern was observed in mandibular/alveolar bone; FasL was detected in osteoblasts at the E15.5 and the number of positive cells decreased at later stages. Importantly, FasL expression did not copy the apoptosis pattern suggesting non-apoptotic engagement in formation of hard tissues. Additionally, preliminary results of microCT analysis of the adult gld mice showed increased enamel volume in molars but no impact on crown formation. Detailed analysis of bone parameters is in progress to support the data pointing to dual function of Fas/FasL in odontogenesis and osteogenesis. Among activation of apoptotic machinery, Fas (CD95)/FasL (CD178) were suggested to act in cell proliferation and differentiation. Expression of Fas and FasL was reported during tooth and bone formation. The examination of gld mice showed increased total body bone mass and number of osteoblasts in long bones. However, Fas and FasL functions in osteogenesis remain controversial. As most of studies dealing with Fas/FasL system in bone formation were performed in endochondral models, we turned to intramembranous bones. The aim of our study was to investigate functions of FasL in development of the mandibular and alveolar bones using immunohistochemistry and impact of FasL deficiency by microCT examination of gld mice. This project continues our earlier published investigations of Fas/FasL in prenatal molar tooth development. Heads at embryonic (E) 12.5, 15.5, 17.5 and postnatal (P) 0, 1, 4, 11 days were used for immunohistochemical analysis. FasL was localized in the dental epithelium, dental follicle and a few cells of the dental papilla. In general, as the tooth development progressed, FasL expression decreased. Notably, similar pattern was observed in mandibular/alveolar bone; FasL was detected in osteoblasts at the E15.5 and the number of positive cells decreased at later stages. Importantly, FasL expression did not copy the apoptosis pattern suggesting non-apoptotic engagement in formation of hard tissues. Additionally, preliminary results of microCT analysis of the adult gld mice showed increased enamel volume in molars but no impact on crown formation. Detailed analysis of bone parameters is in progress to support the data pointing to dual function of Fas/FasL in odontogenesis and osteogenesis.
dcterms:title
Fas ligand in formation of hard tissues Fas ligand in formation of hard tissues
skos:prefLabel
Fas ligand in formation of hard tissues Fas ligand in formation of hard tissues
skos:notation
RIV/62157124:16170/14:43873327!RIV15-MSM-16170___
n3:aktivita
n16:I
n3:aktivity
I
n3:dodaniDat
n15:2015
n3:domaciTvurceVysledku
n12:4002032
n3:druhVysledku
n9:O
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
16489
n3:idVysledku
RIV/62157124:16170/14:43873327
n3:jazykVysledku
n8:eng
n3:klicovaSlova
microCT; hard tissue; FasL; Fas
n3:klicoveSlovo
n4:microCT n4:FasL n4:hard%20tissue n4:Fas
n3:kontrolniKodProRIV
[23222F325B45]
n3:obor
n14:GJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n15:2014
n3:tvurceVysledku
Lesot, Hervé LeDenmat, Dominique Matalová, Eva Poliard, Anne Oralová, Veronika Švandová, Eva
n7:organizacniJednotka
16170