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Statements

Subject Item
n2:RIV%2F62157124%3A16170%2F14%3A43873320%21RIV15-MSM-16170___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation induced by ADP was significantly reduced after 2 weeks in both experimental groups (R: P{0.01; RG: P{0.05) while aggregation induced by cationic propylgallate was significantly reduced only in RG after 2 weeks (P{0.05). Speed of aggregation (slope) induced by ADP significantly decreased after 2 weeks (both R and RG: P{0.01). Speed of aggregation (slope) induced by cationic propylgallate significantly decreased in both experimental groups (R: P{0.05; RG: P{0.01). Results suggest that neither suppressive effect of resveratrol on platelet numbers nor its %22aspirin-like%22 effect is inhibited by simultaneous administration of beta-glucan. On the contrary we demonstrated synergistic effect of both agents in experimental piglets. The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation induced by ADP was significantly reduced after 2 weeks in both experimental groups (R: P{0.01; RG: P{0.05) while aggregation induced by cationic propylgallate was significantly reduced only in RG after 2 weeks (P{0.05). Speed of aggregation (slope) induced by ADP significantly decreased after 2 weeks (both R and RG: P{0.01). Speed of aggregation (slope) induced by cationic propylgallate significantly decreased in both experimental groups (R: P{0.05; RG: P{0.01). Results suggest that neither suppressive effect of resveratrol on platelet numbers nor its %22aspirin-like%22 effect is inhibited by simultaneous administration of beta-glucan. On the contrary we demonstrated synergistic effect of both agents in experimental piglets.
dcterms:title
Synergistic effects of beta-glucan and resveratrol on platelet aggregation Synergistic effects of beta-glucan and resveratrol on platelet aggregation
skos:prefLabel
Synergistic effects of beta-glucan and resveratrol on platelet aggregation Synergistic effects of beta-glucan and resveratrol on platelet aggregation
skos:notation
RIV/62157124:16170/14:43873320!RIV15-MSM-16170___
n3:aktivita
n7:I
n3:aktivity
I
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n12:5997933 n12:9388583 n12:8914427 n12:5442125
n3:druhVysledku
n8:O
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
48924
n3:idVysledku
RIV/62157124:16170/14:43873320
n3:jazykVysledku
n15:eng
n3:klicovaSlova
pig; platelet aggregation; resveratrol; beta-glucan
n3:klicoveSlovo
n11:resveratrol n11:beta-glucan n11:platelet%20aggregation n11:pig
n3:kontrolniKodProRIV
[79A594D5FA49]
n3:obor
n13:GJ
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2014
n3:tvurceVysledku
Chlastáková, Ivana Tomenendálová, Jaroslava Doubek, Jaroslav Kotrbáček, Václav
n4:organizacniJednotka
16170