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Statements

Subject Item
n2:RIV%2F62157124%3A16170%2F12%3A43871649%21RIV13-MSM-16170___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The effect of enrofloxacin on the QT interval of the electrocardiogram was studied in 30 hospitalized dogs. The experimental group (n = 15) received enrofloxacin parenterally (subcutaneously) at a dose of 5 mg/kg twice daily and amoxicillin-clavulanate intravenously at a dose of 22 mg/kg three times daily. The control group (n = 15) received only amoxicillin-clavulanate. Electrocardiography was carried out for 5 min once daily for 6 days. The QT interval was corrected by four different formulae. No differences were found between the two groups or within each group for the duration of the study. On the last day of the study the average QT interval for the control and experimental groups was 213.2 ms and 202.9 ms, respectively. Enrofloxacin did not cause prolongation of the QT or corrected QT intervals. We can conclude that the parenteral administration of enrofloxacin in non-cardiac dogs does not adversely affect the electrocardiographic indicators (no prolongation of the QT or corrected QT interval) and does not induce ventricular arrhythmias. Parenteral use of enrofloxacin is thus safe and effective in non-cardiac dogs. The effect of enrofloxacin on the QT interval of the electrocardiogram was studied in 30 hospitalized dogs. The experimental group (n = 15) received enrofloxacin parenterally (subcutaneously) at a dose of 5 mg/kg twice daily and amoxicillin-clavulanate intravenously at a dose of 22 mg/kg three times daily. The control group (n = 15) received only amoxicillin-clavulanate. Electrocardiography was carried out for 5 min once daily for 6 days. The QT interval was corrected by four different formulae. No differences were found between the two groups or within each group for the duration of the study. On the last day of the study the average QT interval for the control and experimental groups was 213.2 ms and 202.9 ms, respectively. Enrofloxacin did not cause prolongation of the QT or corrected QT intervals. We can conclude that the parenteral administration of enrofloxacin in non-cardiac dogs does not adversely affect the electrocardiographic indicators (no prolongation of the QT or corrected QT interval) and does not induce ventricular arrhythmias. Parenteral use of enrofloxacin is thus safe and effective in non-cardiac dogs.
dcterms:title
Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs. Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs.
skos:prefLabel
Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs. Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs.
skos:notation
RIV/62157124:16170/12:43871649!RIV13-MSM-16170___
n10:predkladatel
n13:orjk%3A16170
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n8:1031279 n8:2132087 n8:5997933
n3:druhVysledku
n9:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
133481
n3:idVysledku
RIV/62157124:16170/12:43871649
n3:jazykVysledku
n14:eng
n3:klicovaSlova
ECG; Canine; repolarization; QT interval; Quinolone
n3:klicoveSlovo
n6:QT%20interval n6:repolarization n6:ECG n6:Canine n6:Quinolone
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[44D7944132E0]
n3:nazevZdroje
Acta veterinaria Brno
n3:obor
n17:GJ
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
81
n3:tvurceVysledku
Agudelo, Carlos F. Scheer, Peter Tomenendálová, Jaroslava
s:issn
0001-7213
s:numberOfPages
6
n15:doi
10.2754/avb201281040409
n19:organizacniJednotka
16170