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Statements

Subject Item
n2:RIV%2F62157124%3A16170%2F12%3A43871256%21RIV13-MSM-16170___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The aim of the study was to assess the efficacy of using a Gn-RH agonist implant (deslorelin 4.7 mg, Suprelorin(R)) to control sexual activity of male cats and reestablishment of sexual function after the implant removal four months after placement. Using a control group (Group 1, n = 5), 22 domestic tomcats were given the implant subcutaneously in the region of the right shoulder blade and were then divided into two treatment groups. Animals in Group 2 (n = 14) were observed from the date of implant surgery and the observation lasted for four months. In Group 3 (n = 8) all animals were monitored from the date of implant surgery. Then, after four months, all implants were removed and the toms were observed for a further four months. In all animals during their first visit and then in one-month intervals, changes in testosterone concentrations were assessed before (T0) and four hours after (T4) human chorionic gonadotropin (HCG) administration and testis size was measured. In all tomcats, semen collection was performed, using an electroejaculator, in the course of the first visit and then in two-month intervals or at the end of observation. Total sperm count was determined in each semen sample. Two to four animals were castrated at weeks 4, 8, 12, 16, 20, 24, 28 and 32 and histological assessment of the testes was performed. By evaluation of 200 cross-sections of seminiferous tubules, the degree of spermatogenic suppression was assessed and animals in groups 2 and 3 were assigned into groups according to the majority of tubules with the most developed germ cell observed: G1, spermatocytes; G2, round spermatids; G3, elongating spermatids and G4, elongated spermatids. The mean area of Leydig-cell nuclei was calculated. In animals in Group 2, suppression after implant insertion was monitored. T4 concentrations, testis size, and total sperm count gradually decreased (P { 0.01; P { 0.01; and P { 0.05 respectively) within four months after implantation. The aim of the study was to assess the efficacy of using a Gn-RH agonist implant (deslorelin 4.7 mg, Suprelorin(R)) to control sexual activity of male cats and reestablishment of sexual function after the implant removal four months after placement. Using a control group (Group 1, n = 5), 22 domestic tomcats were given the implant subcutaneously in the region of the right shoulder blade and were then divided into two treatment groups. Animals in Group 2 (n = 14) were observed from the date of implant surgery and the observation lasted for four months. In Group 3 (n = 8) all animals were monitored from the date of implant surgery. Then, after four months, all implants were removed and the toms were observed for a further four months. In all animals during their first visit and then in one-month intervals, changes in testosterone concentrations were assessed before (T0) and four hours after (T4) human chorionic gonadotropin (HCG) administration and testis size was measured. In all tomcats, semen collection was performed, using an electroejaculator, in the course of the first visit and then in two-month intervals or at the end of observation. Total sperm count was determined in each semen sample. Two to four animals were castrated at weeks 4, 8, 12, 16, 20, 24, 28 and 32 and histological assessment of the testes was performed. By evaluation of 200 cross-sections of seminiferous tubules, the degree of spermatogenic suppression was assessed and animals in groups 2 and 3 were assigned into groups according to the majority of tubules with the most developed germ cell observed: G1, spermatocytes; G2, round spermatids; G3, elongating spermatids and G4, elongated spermatids. The mean area of Leydig-cell nuclei was calculated. In animals in Group 2, suppression after implant insertion was monitored. T4 concentrations, testis size, and total sperm count gradually decreased (P { 0.01; P { 0.01; and P { 0.05 respectively) within four months after implantation.
dcterms:title
Reversible suppression of sexual activity in tomcats with deslorelin implant Reversible suppression of sexual activity in tomcats with deslorelin implant
skos:prefLabel
Reversible suppression of sexual activity in tomcats with deslorelin implant Reversible suppression of sexual activity in tomcats with deslorelin implant
skos:notation
RIV/62157124:16170/12:43871256!RIV13-MSM-16170___
n10:predkladatel
n11:orjk%3A16170
n3:aktivita
n18:Z n18:S
n3:aktivity
S, Z(MZE0002716202)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n8:1949950 n8:2220873 n8:1469789 n8:4816676 n8:7121946
n3:druhVysledku
n20:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
165392
n3:idVysledku
RIV/62157124:16170/12:43871256
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Histological evaluation; Semen collection; Testis size; Male cat; GnRH-agonist
n3:klicoveSlovo
n9:GnRH-agonist n9:Semen%20collection n9:Histological%20evaluation n9:Male%20cat n9:Testis%20size
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AC308AF89958]
n3:nazevZdroje
Teriogenology
n3:obor
n6:FP
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
78
n3:tvurceVysledku
Čížek, Petr Přinosilová, Petra Janošovská, Michaela Novotný, Robert Bartošková, Alena Vitásek, Roman
n3:wos
000307622200019
n3:zamer
n5:MZE0002716202
s:issn
0093-691X
s:numberOfPages
10
n19:doi
10.1016/j.theriogenology.2012.03.035
n13:organizacniJednotka
16170