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Statements

Subject Item
n2:RIV%2F62157124%3A16170%2F01%3A00000745%21RIV%2F2002%2FMSM%2F161702%2FN
rdf:type
n6:Vysledek skos:Concept
dcterms:description
: The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial phase of ther : The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial phase of ther
dcterms:title
Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio
skos:prefLabel
Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio
skos:notation
RIV/62157124:16170/01:00000745!RIV/2002/MSM/161702/N
n3:strany
313 - 320
n3:aktivita
n17:Z
n3:aktivity
Z(MSM 161700001)
n3:cisloPeriodika
3
n3:dodaniDat
n16:2002
n3:domaciTvurceVysledku
n10:3176401 n10:9201041
n3:druhVysledku
n8:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
679731
n3:idVysledku
RIV/62157124:16170/01:00000745
n3:jazykVysledku
n18:eng
n3:klicovaSlova
o,p´- DDD, immunoreactive cortisol in urine, selective adrenocorticolysis, iatrogenic hypoadrenocorticism
n3:klicoveSlovo
n5:o n5:selective%20adrenocorticolysis n5:immunoreactive%20cortisol%20in%20urine n5:p%C2%B4-%20DDD n5:iatrogenic%20hypoadrenocorticism
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[BBB45F232B9A]
n3:nazevZdroje
Acta veterinaria
n3:obor
n9:GJ
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n16:2001
n3:svazekPeriodika
70
n3:tvurceVysledku
Kolevská, Jana Svoboda, Miroslav
n3:zamer
n4:MSM%20161700001
s:issn
0001-7213
s:numberOfPages
8
n11:organizacniJednotka
16170