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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F14%3A00224199%21RIV15-MSM-43210___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.agriculturejournals.cz/publicFiles/133214.pdf
dcterms:description
A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr) and low density lipoprotein receptor (Ldlr) was tested in rats fed a diet with 3% of fish oil (FO). Expression of the Insig-1 gene in the liver of the FO-fed rats was 730%(P < 0.05) of the control. However, contrary to the hypothesis, expression of the Hmgcr gene and Ldlr gene was 165% and 210% of the control (P > 0.05). Nevertheless, FO in the diet decreased (P < 0.05) plasma cholesterol of rats by 10% (from 1.19 to 1.07 mmol/l); it was therefore concluded that the cholesterol-lowering effect of EPA+DHA is at least partly based on mechanisms other than tested in the present experiment. A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr) and low density lipoprotein receptor (Ldlr) was tested in rats fed a diet with 3% of fish oil (FO). Expression of the Insig-1 gene in the liver of the FO-fed rats was 730%(P < 0.05) of the control. However, contrary to the hypothesis, expression of the Hmgcr gene and Ldlr gene was 165% and 210% of the control (P > 0.05). Nevertheless, FO in the diet decreased (P < 0.05) plasma cholesterol of rats by 10% (from 1.19 to 1.07 mmol/l); it was therefore concluded that the cholesterol-lowering effect of EPA+DHA is at least partly based on mechanisms other than tested in the present experiment.
dcterms:title
Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level
skos:prefLabel
Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level
skos:notation
RIV/62156489:43210/14:00224199!RIV15-MSM-43210___
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
9
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n5:6082572 n5:3925439 n5:4707338 n5:1297821 n5:2529157 n5:5655463 n5:6373097
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
13226
n3:idVysledku
RIV/62156489:43210/14:00224199
n3:jazykVysledku
n15:eng
n3:klicovaSlova
SREBP-2; Insig-1; cholesterol; PUFAn-3; rats; PPARalpha
n3:klicoveSlovo
n4:rats n4:Insig-1 n4:SREBP-2 n4:PPARalpha n4:PUFAn-3 n4:cholesterol
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[2B2C36735C51]
n3:nazevZdroje
Czech Journal of Animal Science
n3:obor
n7:CE
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
59
n3:tvurceVysledku
Knoll, Aleš Krobot, Richard Rozíková, Veronika Komprda, Tomáš Škultéty, Ondrej Vykoukalová, Zuzana Zorníková, Gabriela
n3:wos
344194600001
s:issn
1212-1819
s:numberOfPages
8
n11:organizacniJednotka
43210