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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F13%3A00213992%21RIV14-MSM-43210___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/9781118636299.ch16/summary
dcterms:description
This review provides a brief overview of the variety of carriers employed for targeted delivery used in gene and cancer therapy summarizing advantages and disadvantages of each approach. Particularly, we aim our attention at magnetic particles and particles made from other materials with various surface modification (oligonucleotides, DNA, RNA, siRNA, miRNA, polyethylene glycol, poly(lactic-co-glycolic acid)). Moreover, we pay attention to magnetofection as one of the promising approach for gene therapy. Further, we briefly focus on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, cisplatin, curcumin, fluorouracil and geldanamycin), antiviral/bacterial agents (peptides, antibiotics, antivirotics) and/or nucleic acids encapsulate in delivery nanotechnology system. The influence of their combination with aforementioned nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility is discussed. This review provides a brief overview of the variety of carriers employed for targeted delivery used in gene and cancer therapy summarizing advantages and disadvantages of each approach. Particularly, we aim our attention at magnetic particles and particles made from other materials with various surface modification (oligonucleotides, DNA, RNA, siRNA, miRNA, polyethylene glycol, poly(lactic-co-glycolic acid)). Moreover, we pay attention to magnetofection as one of the promising approach for gene therapy. Further, we briefly focus on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, cisplatin, curcumin, fluorouracil and geldanamycin), antiviral/bacterial agents (peptides, antibiotics, antivirotics) and/or nucleic acids encapsulate in delivery nanotechnology system. The influence of their combination with aforementioned nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility is discussed.
dcterms:title
Nanoparticles-based carriers for gene therapy and drug delivery Nanoparticles-based carriers for gene therapy and drug delivery
skos:prefLabel
Nanoparticles-based carriers for gene therapy and drug delivery Nanoparticles-based carriers for gene therapy and drug delivery
skos:notation
RIV/62156489:43210/13:00213992!RIV14-MSM-43210___
n14:predkladatel
n15:orjk%3A43210
n3:aktivita
n17:O
n3:aktivity
O
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n6:4995775 n6:2032279 n6:4489705 n6:7333323 n6:5204046 n6:2307049 n6:6359914
n3:druhVysledku
n10:C
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n22:predkladatel
n3:idSjednocenehoVysledku
90610
n3:idVysledku
RIV/62156489:43210/13:00213992
n3:jazykVysledku
n16:eng
n3:klicovaSlova
gene therapy; nanoparticles; magnetic particles
n3:klicoveSlovo
n8:nanoparticles n8:magnetic%20particles n8:gene%20therapy
n3:kontrolniKodProRIV
[007A62A1562C]
n3:mistoVydani
New York
n3:nazevEdiceCisloSvazku
1
n3:nazevZdroje
Nanomedicine for drug delivery and therapeutics
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
7
n3:pocetStranKnihy
449
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n7:2013
n3:tvurceVysledku
Drbohlavová, Jana Adam, Vojtěch Šmerková, Kristýna Šobrová, Pavlína Hubálek, Jaromír Chomoucká, Jana Kizek, René Kopel, Pavel Vaculovičová, Markéta
s:numberOfPages
23
n18:doi
10.1002/9781118636299.ch16
n21:hasPublisher
Wiley, Scrivener Publishing
n20:isbn
978-1-118-41409-5
n12:organizacniJednotka
43210