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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F13%3A00213590%21RIV14-AV0-43210___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Many compounds can interact with DNA leading to changes of DNA structure as point mutation and bases excision, which could trigger some metabolic failures, which leads to the changes in DNA structure resulting in cancer. Oxidation of nucleic acid bases belongs to the one of the mostly occurred type of DNA damaging leading to the above mentioned phenomena. The investigation of processes of DNA oxidation damage is topical and electrochemical methods include a versatile and sensitive tool for these purposes. 8-hydroxydeoxyguanosine (8-OHdG) is the most widely accepted marker of DNA damage. Oxidative damage to DNA by free radicals and exposure to ionizing radiation generate several other products within the double helix besides mentioned oxidation products of nucleic acid bases. The basic electrochemical behaviour of nucleic acids bases on various types of carbon electrodes is reviewed. Further, we address our attention on description of oxidation mechanisms and on detection of the most important products of nucleic bases oxidation. The miniaturization of detector coupled with some microfluidic devices is suggested and discussed. The main aim of this review is to report the advantages and features of the electrochemical detection of guanine oxidation product as 8-OHdG and other similarly produced molecules as markers for DNA damage. Many compounds can interact with DNA leading to changes of DNA structure as point mutation and bases excision, which could trigger some metabolic failures, which leads to the changes in DNA structure resulting in cancer. Oxidation of nucleic acid bases belongs to the one of the mostly occurred type of DNA damaging leading to the above mentioned phenomena. The investigation of processes of DNA oxidation damage is topical and electrochemical methods include a versatile and sensitive tool for these purposes. 8-hydroxydeoxyguanosine (8-OHdG) is the most widely accepted marker of DNA damage. Oxidative damage to DNA by free radicals and exposure to ionizing radiation generate several other products within the double helix besides mentioned oxidation products of nucleic acid bases. The basic electrochemical behaviour of nucleic acids bases on various types of carbon electrodes is reviewed. Further, we address our attention on description of oxidation mechanisms and on detection of the most important products of nucleic bases oxidation. The miniaturization of detector coupled with some microfluidic devices is suggested and discussed. The main aim of this review is to report the advantages and features of the electrochemical detection of guanine oxidation product as 8-OHdG and other similarly produced molecules as markers for DNA damage.
dcterms:title
Electrochemical study of DNA damaging by oxidation stress Electrochemical study of DNA damaging by oxidation stress
skos:prefLabel
Electrochemical study of DNA damaging by oxidation stress Electrochemical study of DNA damaging by oxidation stress
skos:notation
RIV/62156489:43210/13:00213590!RIV14-AV0-43210___
n15:predkladatel
n16:orjk%3A43210
n3:aktivita
n13:P
n3:aktivity
P(KAN208130801)
n3:cisloPeriodika
2
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n11:2307049 n11:2104237 n11:4995775 n11:8082146 n11:8740658 n11:6359914
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
72366
n3:idVysledku
RIV/62156489:43210/13:00213590
n3:jazykVysledku
n9:eng
n3:klicovaSlova
oxidative stress; DNA; electrochemical study
n3:klicoveSlovo
n5:DNA n5:oxidative%20stress n5:electrochemical%20study
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[54E5C26991CF]
n3:nazevZdroje
Combinatorial Chemistry & High Throughput Screening
n3:obor
n8:CG
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n19:KAN208130801
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
16
n3:tvurceVysledku
Skaličková, Sylvie Kopel, Pavel Křížková, Soňa Kizek, René Zítka, Ondřej Adam, Vojtěch Babula, Petr
n3:wos
317050800007
s:issn
1386-2073
s:numberOfPages
12
n18:organizacniJednotka
43210