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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F13%3A00199032%21RIV15-MSM-43210___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://www.mdpi.com/1660-4601/10/1/47
dcterms:description
Nanomaterials are structures whose exceptionality is based on their large surface, which is closely connected with reactivity and modification possibilities. Due to these properties nanomaterials are used in textile industry (antibacterial textiles with silver nanoparticles), electronics (high-resolution imaging, logical circuits on the molecular level) and medicine. Medicine represents one of the most important fields of application of nanomaterials. They are investigated in connection with targeted therapy (infectious diseases, malignant diseases) or imaging (contrast agents). Nanomaterials including nanoparticles have a great application potential in the targeted transport of pharmaceuticals. However, there are some negative properties of nanoparticles, which must be carefully solved, as hydrophobic properties leading to instability in aqueous environment, and especially their possible toxicity. Data about toxicity of nanomaterials are still scarce. Due to this fact, in this work we focused on studying of the effect of magnetic nanoparticles (NPs) and modified magnetic nanoparticles (MNPs) on tobacco BY-2 plant cell suspension culture. We aimed at examining the effect of NPs and MNPs on growth, proteosynthesis--total protein content, thiols--reduced (GSH) and oxidized (GSSG) glutathione, phytochelatins PC2-5, glutathione S-transferase (GST) activity and antioxidant activity of BY-2 cells. Whereas the effect of NPs and MNPs on growth of cell suspension culture was only moderate, significant changes were detected in all other biochemical parameters. Significant changes in protein content, phytochelatins levels and GST activity were observed in BY-2 cells treated with MNPs nanoparticles treatment. Changes were also clearly evident in the case of application of NPs. Nanomaterials are structures whose exceptionality is based on their large surface, which is closely connected with reactivity and modification possibilities. Due to these properties nanomaterials are used in textile industry (antibacterial textiles with silver nanoparticles), electronics (high-resolution imaging, logical circuits on the molecular level) and medicine. Medicine represents one of the most important fields of application of nanomaterials. They are investigated in connection with targeted therapy (infectious diseases, malignant diseases) or imaging (contrast agents). Nanomaterials including nanoparticles have a great application potential in the targeted transport of pharmaceuticals. However, there are some negative properties of nanoparticles, which must be carefully solved, as hydrophobic properties leading to instability in aqueous environment, and especially their possible toxicity. Data about toxicity of nanomaterials are still scarce. Due to this fact, in this work we focused on studying of the effect of magnetic nanoparticles (NPs) and modified magnetic nanoparticles (MNPs) on tobacco BY-2 plant cell suspension culture. We aimed at examining the effect of NPs and MNPs on growth, proteosynthesis--total protein content, thiols--reduced (GSH) and oxidized (GSSG) glutathione, phytochelatins PC2-5, glutathione S-transferase (GST) activity and antioxidant activity of BY-2 cells. Whereas the effect of NPs and MNPs on growth of cell suspension culture was only moderate, significant changes were detected in all other biochemical parameters. Significant changes in protein content, phytochelatins levels and GST activity were observed in BY-2 cells treated with MNPs nanoparticles treatment. Changes were also clearly evident in the case of application of NPs.
dcterms:title
Effect of magnetic nanoparticles on tobacco BY-2 cell suspension culture Effect of magnetic nanoparticles on tobacco BY-2 cell suspension culture
skos:prefLabel
Effect of magnetic nanoparticles on tobacco BY-2 cell suspension culture Effect of magnetic nanoparticles on tobacco BY-2 cell suspension culture
skos:notation
RIV/62156489:43210/13:00199032!RIV15-MSM-43210___
n3:aktivita
n6:V n6:I n6:S n6:P
n3:aktivity
I, P(ED1.1.00/02.0068), P(EE2.3.30.0017), P(GA102/08/1546), S, V
n3:cisloPeriodika
1
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n12:6218482 n12:2307049 n12:4995775 n12:8740658 n12:8594716
n3:druhVysledku
n19:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
71599
n3:idVysledku
RIV/62156489:43210/13:00199032
n3:jazykVysledku
n16:eng
n3:klicovaSlova
magnetic particles; nanomaterials; BY-2
n3:klicoveSlovo
n8:BY-2 n8:nanomaterials n8:magnetic%20particles
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[321FE8EEE5E0]
n3:nazevZdroje
International Journal of Environmental Research and Public Health
n3:obor
n17:EE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n9:GA102%2F08%2F1546 n9:EE2.3.30.0017 n9:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
10
n3:tvurceVysledku
Adam, Vojtěch Kudrle, V. Babula, Petr Zítka, Ondřej Kryštofová, Olga Kizek, René Sochor, Jiří
n3:wos
314026400003
s:issn
1660-4601
s:numberOfPages
25
n14:doi
10.3390/ijerph10010047
n18:organizacniJednotka
43210