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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F12%3A00184889%21RIV13-MSM-43210___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA). The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA).
dcterms:title
Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review
skos:prefLabel
Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review
skos:notation
RIV/62156489:43210/12:00184889!RIV13-MSM-43210___
n4:predkladatel
n5:orjk%3A43210
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
1
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n11:5655463
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
133611
n3:idVysledku
RIV/62156489:43210/12:00184889
n3:jazykVysledku
n6:eng
n3:klicovaSlova
cholesterol; PUFAn-3; functional foods; SREBP; PPAR
n3:klicoveSlovo
n18:PPAR n18:PUFAn-3 n18:functional%20foods n18:cholesterol n18:SREBP
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[EBB469A03DEC]
n3:nazevZdroje
Journal of Functional Foods
n3:obor
n19:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
4
n3:tvurceVysledku
Komprda, Tomáš
s:issn
1756-4646
s:numberOfPages
14
n7:doi
10.1016/j.jff.2011.10.008
n12:organizacniJednotka
43210