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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F11%3A00177565%21RIV12-GA0-43210___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
In many developed countries, prostate cancer is the most common male tumour disease. The high incidence and mortality requires early diagnosis, differentiation of aggressive, highly malignant forms from clinically silent forms and understanding of the pathogenesis with its typical metabolic aberrancies (if any) in order to develop new targeted therapies. Prostate cells (including prostate cancer cells) are unique in their relation to zinc ions. Prostate tissue can accumulate these ions in up to tenfold higher concentration than other body cells. These ions influence many cellular processes incl. proliferation, differentiation and apoptosis. Prostate cancer cells lack ability to accumulate zinc. Therefore, zinc ions may be expected to play an important role in the disease pathogenesis, in its propagation and metastatic potential of tumour cells. Intracellular zinc levels are regulated by zinc-binding proteins, especially metallothioneins, and zinc transporters. Zinc level regulation dysfunction has been identified in prostate cancer cells and may thus play an important role in the prostate cancer pathogenesis. Moreover, due to its overproduction by prostate tissue, metallothionein serum levels are elevated and can be used as an important tumour marker. In many developed countries, prostate cancer is the most common male tumour disease. The high incidence and mortality requires early diagnosis, differentiation of aggressive, highly malignant forms from clinically silent forms and understanding of the pathogenesis with its typical metabolic aberrancies (if any) in order to develop new targeted therapies. Prostate cells (including prostate cancer cells) are unique in their relation to zinc ions. Prostate tissue can accumulate these ions in up to tenfold higher concentration than other body cells. These ions influence many cellular processes incl. proliferation, differentiation and apoptosis. Prostate cancer cells lack ability to accumulate zinc. Therefore, zinc ions may be expected to play an important role in the disease pathogenesis, in its propagation and metastatic potential of tumour cells. Intracellular zinc levels are regulated by zinc-binding proteins, especially metallothioneins, and zinc transporters. Zinc level regulation dysfunction has been identified in prostate cancer cells and may thus play an important role in the prostate cancer pathogenesis. Moreover, due to its overproduction by prostate tissue, metallothionein serum levels are elevated and can be used as an important tumour marker.
dcterms:title
Molecular mechanisms of zinc in prostate cancer Molecular mechanisms of zinc in prostate cancer
skos:prefLabel
Molecular mechanisms of zinc in prostate cancer Molecular mechanisms of zinc in prostate cancer
skos:notation
RIV/62156489:43210/11:00177565!RIV12-GA0-43210___
n9:predkladatel
n11:orjk%3A43210
n3:aktivita
n15:P
n3:aktivity
P(GP301/09/P436)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2012
n3:domaciTvurceVysledku
n4:2104237 n4:9600426 n4:4995775 n4:3931315
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
213502
n3:idVysledku
RIV/62156489:43210/11:00177565
n3:jazykVysledku
n18:eng
n3:klicovaSlova
prostate cancer; zinc; pathogenesis
n3:klicoveSlovo
n13:prostate%20cancer n13:pathogenesis n13:zinc
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F81E53063C91]
n3:nazevZdroje
Klinická onkologie
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n19:GP301%2F09%2FP436
n3:rokUplatneniVysledku
n7:2011
n3:svazekPeriodika
24
n3:tvurceVysledku
Masařík, Michal Rovný, Arne Babula, Petr Hrabec, Roman Křížková, Soňa Kizek, René Masaříková, M. Gumulec, Jaromír
s:issn
0862-495X
s:numberOfPages
7
n14:organizacniJednotka
43210