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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F11%3A00173966%21RIV12-AV0-43210___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. Prion protein is a biomolecule naturally occurring in the animal cells. This protein is present in all mammal cells and occurs primarily in neural cells and immune system cells. The main aim of this study was to optimize electrochemical methods for the detection of natural (PrPC) and changed (PrPSC) prion protein. To carry out the main objective a complex study of the electrochemical behaviour of both proteins was required. For this purpose fundamental electrochemical techniques were used. Both of the prions were characterized using different techniques, their limits of detection were found at pM levels and possible ability to change the structure of alpha-helix of natural prion (PrPC) to beta-sheet of the infectious prion (PrPSc) were monitored. Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. Prion protein is a biomolecule naturally occurring in the animal cells. This protein is present in all mammal cells and occurs primarily in neural cells and immune system cells. The main aim of this study was to optimize electrochemical methods for the detection of natural (PrPC) and changed (PrPSC) prion protein. To carry out the main objective a complex study of the electrochemical behaviour of both proteins was required. For this purpose fundamental electrochemical techniques were used. Both of the prions were characterized using different techniques, their limits of detection were found at pM levels and possible ability to change the structure of alpha-helix of natural prion (PrPC) to beta-sheet of the infectious prion (PrPSc) were monitored.
dcterms:title
Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein
skos:prefLabel
Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein
skos:notation
RIV/62156489:43210/11:00173966!RIV12-AV0-43210___
n13:predkladatel
n14:orjk%3A43210
n3:aktivita
n22:P
n3:aktivity
P(GA102/08/1546), P(KAN208130801)
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n4:9100318 n4:4489705 n4:9000240 n4:3955397 n4:4995775 n4:2307049 n4:7333323
n3:druhVysledku
n19:D
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
197025
n3:idVysledku
RIV/62156489:43210/11:00173966
n3:jazykVysledku
n15:eng
n3:klicovaSlova
prion protein; infectious diseases; nerve cells
n3:klicoveSlovo
n6:nerve%20cells n6:infectious%20diseases n6:prion%20protein
n3:kontrolniKodProRIV
[91EE1FC85653]
n3:mistoKonaniAkce
MENDELU
n3:mistoVydani
Brno
n3:nazevZdroje
XI. pracovní setkání fyzikálních chemiků a elektrochemiků
n3:obor
n17:CG
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n20:GA102%2F08%2F1546 n20:KAN208130801
n3:rokUplatneniVysledku
n10:2011
n3:tvurceVysledku
Hubálek, Jaromír Húska, Dalibor Beklová, Miroslava Adam, Vojtěch Majzlík, Petr Kizek, René Šobrová, Pavlína
n3:typAkce
n18:CST
n3:zahajeniAkce
2011-01-01+01:00
s:numberOfPages
3
n12:hasPublisher
Mendelova zemědělská a lesnická univerzita v Brně
n5:isbn
978-80-7375-514-0
n8:organizacniJednotka
43210