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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F10%3A00166579%21RIV12-GA0-43210___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins. Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
dcterms:title
Matrix metalloproteinases Matrix metalloproteinases
skos:prefLabel
Matrix metalloproteinases Matrix metalloproteinases
skos:notation
RIV/62156489:43210/10:00166579!RIV12-GA0-43210___
n3:aktivita
n16:I n16:P
n3:aktivity
I, P(GP301/09/P436), P(IAA401990701), P(NS10200)
n3:cisloPeriodika
31
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n13:8740658 n13:2104237 n13:3931315 n13:2307049 n13:9000240 n13:4995775
n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
269927
n3:idVysledku
RIV/62156489:43210/10:00166579
n3:jazykVysledku
n18:eng
n3:klicovaSlova
matrix metalloproteinases; pathophysiological roles; physiological roles
n3:klicoveSlovo
n5:physiological%20roles n5:pathophysiological%20roles n5:matrix%20metalloproteinases
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[609F95ECB4ED]
n3:nazevZdroje
Current Medicinal Chemistry
n3:obor
n11:CB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:projekt
n7:GP301%2F09%2FP436 n7:IAA401990701 n7:NS10200
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
17
n3:tvurceVysledku
Húska, Dalibor Zítka, Ondřej Kizek, René Průša, Richard Křížková, Soňa Adam, Vojtěch Kukačka, Jiří Masařík, Michal
s:issn
0929-8673
s:numberOfPages
18
n9:organizacniJednotka
43210