This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n7http://localhost/temp/predkladatel/
n17http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/ontology/domain/vavai/
n19http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n5http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F62156489%3A43210%2F10%3A00166511%21RIV12-GA0-43210___/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n11http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F10%3A00166511%21RIV12-GA0-43210___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Ellipticine (5,11-demethyl-6H-pyridol(4,3-b) carbazole) and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytotoxic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine. In additional experiments we investigated the changes in the reduction signal of cytosine/adenine (CA) in a genomic dsDNA, dsDNA treated with ellipticine in vitro and dsDNA isolated from UKF-NB-3 neuroblastoma cells treated with 1 mu M ellipticine. In the mentioned cases, the changes were determined. Ellipticine (5,11-demethyl-6H-pyridol(4,3-b) carbazole) and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytotoxic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine. In additional experiments we investigated the changes in the reduction signal of cytosine/adenine (CA) in a genomic dsDNA, dsDNA treated with ellipticine in vitro and dsDNA isolated from UKF-NB-3 neuroblastoma cells treated with 1 mu M ellipticine. In the mentioned cases, the changes were determined.
dcterms:title
An electrochemical study of interaction of an anticancer alkaloid ellipticine with DNA An electrochemical study of interaction of an anticancer alkaloid ellipticine with DNA
skos:prefLabel
An electrochemical study of interaction of an anticancer alkaloid ellipticine with DNA An electrochemical study of interaction of an anticancer alkaloid ellipticine with DNA
skos:notation
RIV/62156489:43210/10:00166511!RIV12-GA0-43210___
n4:aktivita
n13:Z n13:I n13:P
n4:aktivity
I, P(1M0505), P(GA102/08/1546), P(GAP301/10/0356), P(KAN208130801), Z(MSM0021620808)
n4:cisloPeriodika
5
n4:dodaniDat
n11:2012
n4:domaciTvurceVysledku
n10:2104237 n10:2307049 n10:4995775 n10:9000240
n4:druhVysledku
n16:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
246195
n4:idVysledku
RIV/62156489:43210/10:00166511
n4:jazykVysledku
n18:eng
n4:klicovaSlova
anticancer alkaloid; DNA; voltammetry
n4:klicoveSlovo
n14:voltammetry n14:DNA n14:anticancer%20alkaloid
n4:kodStatuVydavatele
IT - Italská republika
n4:kontrolniKodProRIV
[36EB1ED3EBCE]
n4:nazevZdroje
Chimica Oggi
n4:obor
n8:CG
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
7
n4:projekt
n17:1M0505 n17:GA102%2F08%2F1546 n17:GAP301%2F10%2F0356 n17:KAN208130801
n4:rokUplatneniVysledku
n11:2010
n4:svazekPeriodika
28
n4:tvurceVysledku
Eckschlager, Tomáš Hraběta, Jan Stiborová, Marie Húska, Dalibor Adam, Vojtěch Kizek, René Křížková, Soňa
n4:zamer
n19:MSM0021620808
s:issn
0392-839X
s:numberOfPages
3
n7:organizacniJednotka
43210