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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F10%3A00160935%21RIV11-MZE-43210___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined by visual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsatellite (HTG004 Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined by visual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsatellite (HTG004
dcterms:title
Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?
skos:prefLabel
Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?
skos:notation
RIV/62156489:43210/10:00160935!RIV11-MZE-43210___
n4:aktivita
n6:P
n4:aktivity
P(QH92277)
n4:dodaniDat
n10:2011
n4:domaciTvurceVysledku
n5:8123462 n5:3671615
n4:druhVysledku
n9:O
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
260386
n4:idVysledku
RIV/62156489:43210/10:00160935
n4:jazykVysledku
n17:eng
n4:klicovaSlova
melanoma; rezistance; Kladruber horse
n4:klicoveSlovo
n12:Kladruber%20horse n12:rezistance n12:melanoma
n4:kontrolniKodProRIV
[C9258B206595]
n4:obor
n16:EB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
9
n4:projekt
n13:QH92277
n4:rokUplatneniVysledku
n10:2010
n4:tvurceVysledku
Hořín, Petr Hofmanová, Barbora Vychodilová, Leona Majzlík, Ivan Vyskočil, Mirko Vrtková, Irena Putnová, Lenka Vránová, Marie Futas, Ján
n8:organizacniJednotka
43210