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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F09%3A00128002%21RIV14-MSM-43210___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolized macrophages (NMAC) after 24 hours. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+NMAC. The lower total count and proportion of CD44+ vacuolized macrophages (VMAC) was observed as the effect of MDP and LPS at 24 hours after induction (P<0.01). During resolution, the total count and proportion of CD44+VMAC increased. We have demonstrated CD44 receptor is expressed during the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response. High expression of CD44 in resolution of inflammatory response may relate to macrophages' involvement in the processes leading to restitution of injured tissues. The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolized macrophages (NMAC) after 24 hours. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+NMAC. The lower total count and proportion of CD44+ vacuolized macrophages (VMAC) was observed as the effect of MDP and LPS at 24 hours after induction (P<0.01). During resolution, the total count and proportion of CD44+VMAC increased. We have demonstrated CD44 receptor is expressed during the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response. High expression of CD44 in resolution of inflammatory response may relate to macrophages' involvement in the processes leading to restitution of injured tissues.
dcterms:title
Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide
skos:prefLabel
Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide
skos:notation
RIV/62156489:43210/09:00128002!RIV14-MSM-43210___
n3:aktivita
n6:Z n6:S n6:P
n3:aktivity
P(GA524/03/1531), S, Z(MZE0002716201)
n3:cisloPeriodika
2
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n12:9869522
n3:druhVysledku
n20:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
314417
n3:idVysledku
RIV/62156489:43210/09:00128002
n3:jazykVysledku
n15:eng
n3:klicovaSlova
murymyl dipeptide; lipopolysaccharide; inflammatory response; macrophage; CD44
n3:klicoveSlovo
n10:murymyl%20dipeptide n10:lipopolysaccharide n10:macrophage n10:CD44 n10:inflammatory%20response
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4E839328E129]
n3:nazevZdroje
Research in Veterinary Science
n3:obor
n17:GJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n9:GA524%2F03%2F1531
n3:rokUplatneniVysledku
n4:2009
n3:svazekPeriodika
86
n3:tvurceVysledku
Sládek, Zbyšek Ryšánek, Dušan
n3:wos
264244800009
n3:zamer
n19:MZE0002716201
s:issn
0034-5288
s:numberOfPages
6
n18:doi
10.1016/j.rvsc.2008.07.016
n16:organizacniJednotka
43210