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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F06%3A00103447%21RIV07-GA0-43210___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Byli popsány 4 třídy metalothioneinu. Lidský metalothionein patří do první skupiny a jsou kódovány rodinou s deseti isofomami. Pro jejich schopnosti vytvářet komplexy s kovy jako je zinek, kadmium apod. má důležitou fyziologickou funkci v regulaci hladin těchto iontu v organizmu. Je pravděpodobné, že sehrávají úlohu v nádorové rezistenci při léčbě platinovými cytostatiky. V této práci jsme zkoumali interakci platinových cytostatik s MT a koncentraci MT u nádorových liniích. My jsme použily buněčné linie z neuroblastomu a to linie rezistentní (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP) a senzitivní (UKF-NB 2, UKF-NB 3 and UKF-NB 4). Přítomnost cisplatiny u buněčných linií spustí tvorbu thiolových látek, jejich množství vzrostlo až o 1000% v porovnání s kontrolou.. Four classes of metallothioneins (MT1, MT2, MT3 and MT4) have been described until now. Human metallothioneins belongs to I. class of metallothioneins (MT1) and are encoded by gene family with 10 isoforms. Due to their high affinity to heavy metals e.g. zinc, copper and/or cadmium, homeostatic control and detoxification of the metals are their main physiological function at evolutionary different animal organisms. Moreover, it has been discussed that expression of MT could relate with resistance to a treatment by anticancer drugs based on heavy metals, most of all, platinum group metals. The aim of this work was to investigate interactions of MT with cisplatin and to determine a content of MT at tumour cell lines. We used cell lines obtained from neuroblastome that were cisplatin sensitive (UKF-NB 2, UKF-NB 3 and UKF-NB 4) and/or cisplatin resistant (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP). The samples were analysed with AUTOLAB Analyser (EcoChemie, Netherlands). The supporting electrolyte c Four classes of metallothioneins (MT1, MT2, MT3 and MT4) have been described until now. Human metallothioneins belongs to I. class of metallothioneins (MT1) and are encoded by gene family with 10 isoforms. Due to their high affinity to heavy metals e.g. zinc, copper and/or cadmium, homeostatic control and detoxification of the metals are their main physiological function at evolutionary different animal organisms. Moreover, it has been discussed that expression of MT could relate with resistance to a treatment by anticancer drugs based on heavy metals, most of all, platinum group metals. The aim of this work was to investigate interactions of MT with cisplatin and to determine a content of MT at tumour cell lines. We used cell lines obtained from neuroblastome that were cisplatin sensitive (UKF-NB 2, UKF-NB 3 and UKF-NB 4) and/or cisplatin resistant (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP). The samples were analysed with AUTOLAB Analyser (EcoChemie, Netherlands). The supporting electrolyte c
dcterms:title
Increase in content of metallothionein as marker of resistance to cisplatin treatment Význam zvýšení obsahu metalothioneinu v rezistenci k léčbě cisplatinou Increase in content of metallothionein as marker of resistance to cisplatin treatment
skos:prefLabel
Increase in content of metallothionein as marker of resistance to cisplatin treatment Význam zvýšení obsahu metalothioneinu v rezistenci k léčbě cisplatinou Increase in content of metallothionein as marker of resistance to cisplatin treatment
skos:notation
RIV/62156489:43210/06:00103447!RIV07-GA0-43210___
n5:strany
A174;A175
n5:aktivita
n10:P
n5:aktivity
P(GP525/04/P132)
n5:cisloPeriodika
6
n5:dodaniDat
n8:2007
n5:domaciTvurceVysledku
n12:4995775 n12:2307049 n12:8740658 n12:3050106
n5:druhVysledku
n6:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n15:predkladatel
n5:idSjednocenehoVysledku
479173
n5:idVysledku
RIV/62156489:43210/06:00103447
n5:jazykVysledku
n11:eng
n5:klicovaSlova
cancer; cisplatin; metallothionein
n5:klicoveSlovo
n9:metallothionein n9:cisplatin n9:cancer
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[8AAABDE1D749]
n5:nazevZdroje
Clinical chemistry
n5:obor
n14:CG
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
9
n5:projekt
n13:GP525%2F04%2FP132
n5:rokUplatneniVysledku
n8:2006
n5:svazekPeriodika
52
n5:tvurceVysledku
Eckschlager, Tomáš Adam, Vojtěch Kizek, René Zítka, Ondřej Blaštík, Ondřej Beklová, Miroslava Svoboda, Michal Průša, Richard
s:issn
0009-9147
s:numberOfPages
2
n7:organizacniJednotka
43210