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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F06%3A00103406%21RIV07-GA0-43210___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly decrease therap Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly decrease therap Glutathion a metalothionein hrají v organizmu klíčovou roly v detoxifikaci organizmu před různými chemickými látkami. Vzhledem k jejich vyšší afinitě k těžkým kovům udržují jejich homeostázu v organizmu, což je jednou z jejich hlavních fyziologických funkcí. V této práci jsme studovali interakci glutathionu redukovaného a oxidovaného, nitrosoglutathionu a MT s platinovými cytostatiky (cisplatin, carboplatin and oxaliplatin). Použili jsme více voltametrických technik (cyklickou voltametrii, diferenční pulsní voltametrii) v trojelektrodovém uspořádání. Zjistil jsme, že signál GSH se snižoval z přibývající koncentrací těžkého kovu. Navíc přítomnost těžkého kovu katalyzovala rozklad GSNO. MT snižuje terapeutickou koncentraci platinových cytostatik.
dcterms:title
Studium interakce glutathionu a metalothioneinu s cytostatiky Study of interaction of glutathiones and metallothionein with cytostatics Study of interaction of glutathiones and metallothionein with cytostatics
skos:prefLabel
Studium interakce glutathionu a metalothioneinu s cytostatiky Study of interaction of glutathiones and metallothionein with cytostatics Study of interaction of glutathiones and metallothionein with cytostatics
skos:notation
RIV/62156489:43210/06:00103406!RIV07-GA0-43210___
n3:strany
A175;A175
n3:aktivita
n6:P
n3:aktivity
P(GP525/04/P132)
n3:cisloPeriodika
6
n3:dodaniDat
n11:2007
n3:domaciTvurceVysledku
n12:2307049 n12:8659443
n3:druhVysledku
n4:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
502270
n3:idVysledku
RIV/62156489:43210/06:00103406
n3:jazykVysledku
n13:eng
n3:klicovaSlova
cisplatin; cytostatics; glutathione
n3:klicoveSlovo
n5:cytostatics n5:glutathione n5:cisplatin
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7ABCEA2D9E21]
n3:nazevZdroje
Clinical chemistry
n3:obor
n14:CG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n15:GP525%2F04%2FP132
n3:rokUplatneniVysledku
n11:2006
n3:svazekPeriodika
52
n3:tvurceVysledku
Petrlová, Jitka Kukačka, Jiří Adam, Vojtěch Sures, Bernd Kizek, René Beklová, Miroslava Průša, Richard
s:issn
0009-9147
s:numberOfPages
1
n7:organizacniJednotka
43210