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Statements

Subject Item
n2:RIV%2F62156489%3A43210%2F05%3A00086818%21RIV06-GA0-43210___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients'serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy of neoplastic d Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients'serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy of neoplastic d Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients'serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy of neoplastic d
dcterms:title
The influence of platinum-based drugs on the amount of metallothionein The influence of platinum-based drugs on the amount of metallothionein Vliv léků na bázi platiny na množství metalothionein
skos:prefLabel
The influence of platinum-based drugs on the amount of metallothionein The influence of platinum-based drugs on the amount of metallothionein Vliv léků na bázi platiny na množství metalothionein
skos:notation
RIV/62156489:43210/05:00086818!RIV06-GA0-43210___
n3:strany
S66;S67
n3:aktivita
n13:P
n3:aktivity
P(GP525/04/P132)
n3:cisloPeriodika
Suppl.1
n3:dodaniDat
n12:2006
n3:domaciTvurceVysledku
n7:4995775 n7:8659443 n7:3050106 n7:2645572
n3:druhVysledku
n6:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
524786
n3:idVysledku
RIV/62156489:43210/05:00086818
n3:jazykVysledku
n8:eng
n3:klicovaSlova
metallothionein; platinum-based drugs
n3:klicoveSlovo
n4:metallothionein n4:platinum-based%20drugs
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[4FAFBA125C06]
n3:nazevZdroje
Toxicology Letters
n3:obor
n10:CG
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n14:GP525%2F04%2FP132
n3:rokUplatneniVysledku
n12:2005
n3:svazekPeriodika
158
n3:tvurceVysledku
Petrlová, Jitka Kízek, René Kukacka, J. Blaštík, Ondřej Zehnálek, Josef Průša, Richard Adam, Vojtěch
s:issn
0378-4274
s:numberOfPages
2
n18:organizacniJednotka
43210