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Statements

Subject Item
n2:RIV%2F61989592%3A15510%2F14%3A33150605%21RIV15-GA0-15510___
rdf:type
skos:Concept n20:Vysledek
rdfs:seeAlso
http://biomed.papers.upol.cz/pdfs/bio/2014/03/16.pdf
dcterms:description
Aim: The rate of rectal cancer locoregional recurrence following radical surgery varies from 4% to 33%. Though the causes are unclear, likely factors include microscopic tumor residues in the lymphatics, positive resection margins and exfoliation of tumor cells and their subsequent intraluminar spread during operation. Other significant factors include type and technique of surgical procedure. Recently, it has been demonstrated that local recurrence may also be associated with the biological behaviour of the tumor and/or with the composition of the cellular microenvironment which creates optimal conditions for the growth and spread of tumor cells. Case report: The presented case here is interesting because the tumour recurred early following a curative surgical procedure with negative resection margins, without positive lymph nodes, without infiltration of the pelvic wall and without distant metastases. Conclusion: In patients with a determined risk of genetically altered tumor field encompassing epithelial or stromal changes, a different treatment strategy, including gene therapy, anti-inflammatory or anti-angiogenic therapy should be chosen to minimize increased tumor risk. Aim: The rate of rectal cancer locoregional recurrence following radical surgery varies from 4% to 33%. Though the causes are unclear, likely factors include microscopic tumor residues in the lymphatics, positive resection margins and exfoliation of tumor cells and their subsequent intraluminar spread during operation. Other significant factors include type and technique of surgical procedure. Recently, it has been demonstrated that local recurrence may also be associated with the biological behaviour of the tumor and/or with the composition of the cellular microenvironment which creates optimal conditions for the growth and spread of tumor cells. Case report: The presented case here is interesting because the tumour recurred early following a curative surgical procedure with negative resection margins, without positive lymph nodes, without infiltration of the pelvic wall and without distant metastases. Conclusion: In patients with a determined risk of genetically altered tumor field encompassing epithelial or stromal changes, a different treatment strategy, including gene therapy, anti-inflammatory or anti-angiogenic therapy should be chosen to minimize increased tumor risk.
dcterms:title
Unusual recurrent rectal carcinoma: A cancer field theory viewpoint Unusual recurrent rectal carcinoma: A cancer field theory viewpoint
skos:prefLabel
Unusual recurrent rectal carcinoma: A cancer field theory viewpoint Unusual recurrent rectal carcinoma: A cancer field theory viewpoint
skos:notation
RIV/61989592:15510/14:33150605!RIV15-GA0-15510___
n3:aktivita
n9:P
n3:aktivity
P(GAP304/10/1070)
n3:cisloPeriodika
3
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n4:5285348
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
52053
n3:idVysledku
RIV/61989592:15510/14:33150605
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cellular microenvironment; recurrence; rectal cancer
n3:klicoveSlovo
n5:rectal%20cancer n5:recurrence n5:cellular%20microenvironment
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[B4186B1E00D7]
n3:nazevZdroje
Biomedical Papers-Olomouc
n3:obor
n16:FJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n10:GAP304%2F10%2F1070
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
158
n3:tvurceVysledku
Skalický, Pavel Brychtová, Svetlana Vysloužil, Kamil Zbořil, Pavel Vomáčková, Katherine Brychta, Tomáš Bezděková, Michala
s:issn
1213-8118
s:numberOfPages
5
n19:doi
10.5507/bp.2012.091
n17:organizacniJednotka
15510