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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F14%3A33152653%21RIV15-AV0-15310___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S1674205214602884
dcterms:description
In plants, the patterning of stem cell-enriched meristems requires a graded auxin response maximum that emerges from the concerted action of polar auxin transport, auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However, mechanisms underlying this auxin response maximum-mediated root stem cell maintenance are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic genes in the quiescent center (QC) of the root and thus provides a robust mechanism for the maintenance of auxin response maximum in the root tip. This WOX5 action is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response repressor. Our combined genetic, cell biology, and computational modeling studies revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback circuit further assures the maintenance of auxin response maximum in the root tip and thereby contributes to the maintenance of distal stem cell (DSC) populations. Our experimental studies and in silico computer simulations both demonstrate that the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip and the auxin-mediated root DSC differentiation. In plants, the patterning of stem cell-enriched meristems requires a graded auxin response maximum that emerges from the concerted action of polar auxin transport, auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However, mechanisms underlying this auxin response maximum-mediated root stem cell maintenance are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic genes in the quiescent center (QC) of the root and thus provides a robust mechanism for the maintenance of auxin response maximum in the root tip. This WOX5 action is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response repressor. Our combined genetic, cell biology, and computational modeling studies revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback circuit further assures the maintenance of auxin response maximum in the root tip and thereby contributes to the maintenance of distal stem cell (DSC) populations. Our experimental studies and in silico computer simulations both demonstrate that the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip and the auxin-mediated root DSC differentiation.
dcterms:title
WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis
skos:prefLabel
WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis
skos:notation
RIV/61989592:15310/14:33152653!RIV15-AV0-15310___
n3:aktivita
n8:Z n8:P
n3:aktivity
P(KAN200380801), P(LO1204), Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n19:3491498 n19:3730832
n3:druhVysledku
n10:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
56386
n3:idVysledku
RIV/61989592:15310/14:33152653
n3:jazykVysledku
n14:eng
n3:klicovaSlova
computer simulation; root patterning; IAA17/AXR3; auxin maximum; WOX5
n3:klicoveSlovo
n9:auxin%20maximum n9:root%20patterning n9:WOX5 n9:computer%20simulation n9:IAA17%2FAXR3
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D2A3E4B2D074]
n3:nazevZdroje
Molecular Plant
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
12
n3:projekt
n15:LO1204 n15:KAN200380801
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
7
n3:tvurceVysledku
Govaerts, Willy Yu, Qianqian Ding, Zhaojun Wabnik, Krzysztof Rolčík, Jakub Niu, Tiantian Friml, Jiří Tian, Huiyu Li, Hanbing Geisler, Markus Pollmann, Stephan Vanneste, Steffen
n3:wos
000330841400003
n3:zamer
n12:MSM6198959216
s:issn
1674-2052
s:numberOfPages
13
n21:doi
10.1093/mp/sst118
n11:organizacniJednotka
15310