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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F13%3A33148296%21RIV14-MSM-15310___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs00204-013-1028-2
dcterms:description
Health beneficial effects of xanthohumol have been reported, and basic research provided evidence for anti-cancer effects. Furthermore, xanthohumol was shown to inhibit the migration of endothelial cells. Therefore, this study investigated the anti-metastatic potential of xanthohumol. MCF-7 breast cancer spheroids which are placed on lymphendothelial cells (LECs) induce %22circular chemorepellent-induced defects%22 (CCIDs) in the LEC monolayer resembling gates for intravasating tumour bulks at an early step of lymph node colonisation. NF-kappa B reporter-, EROD-, SELE-, 12(S)-HETE- and adhesion assays were performed to investigate the anti-metastatic properties of xanthohumol. Western blot analyses were used to elucidate the mechanisms inhibiting CCID formation. Xanthohumol inhibited the activity of CYP, SELE and NF-kB and consequently, the formation of CCIDs at low micromolar concentrations. More specifically, xanthohumol affected ICAM-1 expression and adherence of MCF-7 cells to LECs, which is a prerequisite for CCID formation. Furthermore, markers of epithelial-to-mesenchymal transition (EMT) and of cell mobility such as paxillin, MCL2 and S100A4 were suppressed by xanthohumol. Xanthohumol attenuated tumour cell-mediated defects at the lymphendothelial barrier and inhibited EMT-like effects thereby providing a mechanistic explanation for the anti-intravasative/anti-metastatic properties of xanthohumol Health beneficial effects of xanthohumol have been reported, and basic research provided evidence for anti-cancer effects. Furthermore, xanthohumol was shown to inhibit the migration of endothelial cells. Therefore, this study investigated the anti-metastatic potential of xanthohumol. MCF-7 breast cancer spheroids which are placed on lymphendothelial cells (LECs) induce %22circular chemorepellent-induced defects%22 (CCIDs) in the LEC monolayer resembling gates for intravasating tumour bulks at an early step of lymph node colonisation. NF-kappa B reporter-, EROD-, SELE-, 12(S)-HETE- and adhesion assays were performed to investigate the anti-metastatic properties of xanthohumol. Western blot analyses were used to elucidate the mechanisms inhibiting CCID formation. Xanthohumol inhibited the activity of CYP, SELE and NF-kB and consequently, the formation of CCIDs at low micromolar concentrations. More specifically, xanthohumol affected ICAM-1 expression and adherence of MCF-7 cells to LECs, which is a prerequisite for CCID formation. Furthermore, markers of epithelial-to-mesenchymal transition (EMT) and of cell mobility such as paxillin, MCL2 and S100A4 were suppressed by xanthohumol. Xanthohumol attenuated tumour cell-mediated defects at the lymphendothelial barrier and inhibited EMT-like effects thereby providing a mechanistic explanation for the anti-intravasative/anti-metastatic properties of xanthohumol
dcterms:title
Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis
skos:prefLabel
Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis
skos:notation
RIV/61989592:15310/13:33148296!RIV14-MSM-15310___
n12:predkladatel
n13:orjk%3A15310
n5:aktivita
n15:P
n5:aktivity
P(ED0007/01/01)
n5:cisloPeriodika
7
n5:dodaniDat
n10:2014
n5:domaciTvurceVysledku
n7:6086187 Mikulits, Wolfgang n7:4712048
n5:druhVysledku
n17:J
n5:duvernostUdaju
n9:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
117556
n5:idVysledku
RIV/61989592:15310/13:33148296
n5:jazykVysledku
n19:eng
n5:klicovaSlova
Mobility; Adhesion; Lymph endothelium; Cancer intravasation; Xanthohumol
n5:klicoveSlovo
n6:Xanthohumol n6:Cancer%20intravasation n6:Mobility n6:Lymph%20endothelium n6:Adhesion
n5:kodStatuVydavatele
DE - Spolková republika Německo
n5:kontrolniKodProRIV
[6030C2F19D2D]
n5:nazevZdroje
Archives of Toxicology
n5:obor
n8:ED
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
23
n5:projekt
n16:ED0007%2F01%2F01
n5:rokUplatneniVysledku
n10:2013
n5:svazekPeriodika
87
n5:tvurceVysledku
Atanasov, Atanas Raab, Ingrid Krupitza, Georg Knasmueller, Siegfried Krieger, Sigurd Dirsch, Verena M Teichmann, Mathias Viola, Katharina Saiko, Philipp De Martin, Rainer Szekeres, Thomas Giessrigl, Benedikt Kretschy, Nicole Rárová, Lucie Jäger, Walter Grusch, Michael Vonach, Caroline Dolznig, Helmut Huttary, Nicole Jarukamjorn, Kanokwan Kopf, Sabine Strnad, Miroslav Mikulits, Wolfgang
n5:wos
000320280000011
s:issn
0340-5761
s:numberOfPages
12
n20:doi
10.1007/s00204-013-1028-2
n18:organizacniJednotka
15310