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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F13%3A33147787%21RIV14-MZ0-15310___
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/jbt.21516/pdf
dcterms:description
Sibutramine is a serotonin-norepinephrine reuptake inhibitor that was used for weight-loss management in obese patients. Even though it was officially withdrawn from the market in 2010, it is still present in some tainted weight-loss pills (as reported by US Food and Drug Administration). Thus, it is still reasonable to study the effects of this compound. The aim of this work was to investigate the potential of sibutramine to induce CYP1A1/CY3A4 in human cancer cell lines and CYP1A1/2, CYP2A6, CYP2B6, and CYP3A4 in human hepatocytes, a competent model of metabolically active cells. The levels of mRNA and protein of CYP1A1/1A2/3A4/2A6/2B6 were compared with the typical inducers, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and rifampicin (RIF) for CYP1A1/2 and for other CYPs, respectively. The mRNA and protein levels of all genes in either cancer cell lines or human hepatocytes were induced when treated with typical inducers but not with sibutramine. Human Hepatocytes; CYP3A4; CYP1A2; CYP2A6; CYP2B6 Sibutramine is a serotonin-norepinephrine reuptake inhibitor that was used for weight-loss management in obese patients. Even though it was officially withdrawn from the market in 2010, it is still present in some tainted weight-loss pills (as reported by US Food and Drug Administration). Thus, it is still reasonable to study the effects of this compound. The aim of this work was to investigate the potential of sibutramine to induce CYP1A1/CY3A4 in human cancer cell lines and CYP1A1/2, CYP2A6, CYP2B6, and CYP3A4 in human hepatocytes, a competent model of metabolically active cells. The levels of mRNA and protein of CYP1A1/1A2/3A4/2A6/2B6 were compared with the typical inducers, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and rifampicin (RIF) for CYP1A1/2 and for other CYPs, respectively. The mRNA and protein levels of all genes in either cancer cell lines or human hepatocytes were induced when treated with typical inducers but not with sibutramine. Human Hepatocytes; CYP3A4; CYP1A2; CYP2A6; CYP2B6
dcterms:title
Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines
skos:prefLabel
Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines
skos:notation
RIV/61989592:15310/13:33147787!RIV14-MZ0-15310___
n5:predkladatel
n20:orjk%3A15310
n3:aktivita
n21:S n21:P
n3:aktivity
P(GAP303/12/0472), P(NT13591), S
n3:cisloPeriodika
12
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n10:4908171 n10:8069239 n10:2021064
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
71971
n3:idVysledku
RIV/61989592:15310/13:33147787
n3:jazykVysledku
n16:eng
n3:klicovaSlova
CYP2B6; CYP2A6; CYP1A2; CYP3A4; Human Hepatocytes
n3:klicoveSlovo
n8:CYP2A6 n8:CYP1A2 n8:Human%20Hepatocytes n8:CYP2B6 n8:CYP3A4
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EB6BBCE7B4FB]
n3:nazevZdroje
Journal of Biochemical and Molecular Toxicology
n3:obor
n15:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n13:NT13591 n13:GAP303%2F12%2F0472
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
27
n3:tvurceVysledku
Dvořák, Zdeněk Bachleda, Petr Vrzal, Radim Knoppová, Barbora
n3:wos
000327569400003
s:issn
1095-6670
s:numberOfPages
7
n11:doi
10.1002/jbt.21516
n9:organizacniJednotka
15310