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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F13%3A33147715%21RIV15-MSM-15310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The first nitration of codeine by using bismuth nitrate pentahydrate under mild reaction conditions is described. The resulting 1-nitrocodeine was reduced to 1-aminocodeine, a key precursor for the synthesis of the azo derivative and several hydrazones. Structures of both 1-nitrocodeine and 1-amino-codeine were unequivocally determined by single-crystal Xray analysis. The reported preliminary synthetic study lays the groundwork for the synthesis of modified codeine derivatives with potential biological activity. The first nitration of codeine by using bismuth nitrate pentahydrate under mild reaction conditions is described. The resulting 1-nitrocodeine was reduced to 1-aminocodeine, a key precursor for the synthesis of the azo derivative and several hydrazones. Structures of both 1-nitrocodeine and 1-amino-codeine were unequivocally determined by single-crystal Xray analysis. The reported preliminary synthetic study lays the groundwork for the synthesis of modified codeine derivatives with potential biological activity.
dcterms:title
Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives
skos:prefLabel
Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives
skos:notation
RIV/61989592:15310/13:33147715!RIV15-MSM-15310___
n3:aktivita
n19:P
n3:aktivity
P(ED2.1.00/03.0058), P(EE2.3.20.0017), P(EE2.4.31.0130)
n3:cisloPeriodika
17
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n9:6642152 n9:6884938 n9:8225583 n9:6013449 n9:2321459 n9:4012240
n3:druhVysledku
n6:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
109560
n3:idVysledku
RIV/61989592:15310/13:33147715
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Synthetic methods / Drug design / Fused-ring systems / Diazo compounds / Isotopic labelling / Reduction
n3:klicoveSlovo
n12:Synthetic%20methods%20%2F%20Drug%20design%20%2F%20Fused-ring%20systems%20%2F%20Diazo%20compounds%20%2F%20Isotopic%20labelling%20%2F%20Reduction
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[08AFB91D0A79]
n3:nazevZdroje
European Journal of Organic Chemistry
n3:obor
n10:CC
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n11:EE2.3.20.0017 n11:EE2.4.31.0130 n11:ED2.1.00%2F03.0058
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
2013
n3:tvurceVysledku
Slouka, Jan Popa, Igor Stýskala, Jakub Hradil, Pavel Cankař, Petr Trávníček, Zdeněk
n3:wos
000324302600011
s:issn
1434-193X
s:numberOfPages
7
n14:doi
10.1002/ejoc.201300701
n13:organizacniJednotka
15310