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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F12%3A33142501%21RIV13-MSM-15310___
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0887233312000070
dcterms:description
The 1D-polymeric iron(III) complexes [Fe(salen)(mý-L)]n (1-6), involving a deprotonated form of the N-donor heterocyclic compounds (L) imidazole (complex 1), 1,2,4-triazole (2), benztriazole (3), 5-methyltetrazole (4), 5-aminotetrazole (5) and 5-phenyltetrazole (6), were studied for their in vitro cytotoxic activity against human cancer cell lines including lung carcinoma (A549), cervix epithelial carcinoma (HeLa), osteosarcoma (HOS), malignant melanoma (G361), breast adenocarcinoma (MCF7), ovarian carcinoma (A2780) and cisplatin-resistant ovarian carcinoma (A2780cis). Cytotoxicity in vitro (IC50 = 0.39-0.48 mýM) was achieved for 2-6 against A2780 (IC50 of cisplatin equals 11.5 mýM) as well as for 5 and 6 against all the tested cells, with IC50 = 2.5-37.7 mýM. The Uv-Vis spectroscopic study showed that the complexes are unstable in organic solvents (e.g. dimethyl sulfoxide, dimethylformamide) containing even trace amounts of water (and thus also in the medium, i.e. 0.1% DMF, v/v, used in the MTT assay), where they partially or completely decompose to the mixtures involving, besides [Fe(salen)(mý-L)]n itself, also the starting compounds [{Fe(salen)}2(mý-O)] and appropriate organic compound (HL). In efforts to find how the resulting cytotoxicity of the most active compounds 5 and 6 is influenced by this fact, the in vitro cytotoxicity testing of mixtures of reactants [{Fe(salen)}2(mý-O)] and HL, as well as the respective reactants, was also performed. It has been found that the cytotoxicity of 5 and 6 against all the tested cell lines is probably caused by a combined effect of the individual components presented within the corresponding mixture in the medium used The 1D-polymeric iron(III) complexes [Fe(salen)(mý-L)]n (1-6), involving a deprotonated form of the N-donor heterocyclic compounds (L) imidazole (complex 1), 1,2,4-triazole (2), benztriazole (3), 5-methyltetrazole (4), 5-aminotetrazole (5) and 5-phenyltetrazole (6), were studied for their in vitro cytotoxic activity against human cancer cell lines including lung carcinoma (A549), cervix epithelial carcinoma (HeLa), osteosarcoma (HOS), malignant melanoma (G361), breast adenocarcinoma (MCF7), ovarian carcinoma (A2780) and cisplatin-resistant ovarian carcinoma (A2780cis). Cytotoxicity in vitro (IC50 = 0.39-0.48 mýM) was achieved for 2-6 against A2780 (IC50 of cisplatin equals 11.5 mýM) as well as for 5 and 6 against all the tested cells, with IC50 = 2.5-37.7 mýM. The Uv-Vis spectroscopic study showed that the complexes are unstable in organic solvents (e.g. dimethyl sulfoxide, dimethylformamide) containing even trace amounts of water (and thus also in the medium, i.e. 0.1% DMF, v/v, used in the MTT assay), where they partially or completely decompose to the mixtures involving, besides [Fe(salen)(mý-L)]n itself, also the starting compounds [{Fe(salen)}2(mý-O)] and appropriate organic compound (HL). In efforts to find how the resulting cytotoxicity of the most active compounds 5 and 6 is influenced by this fact, the in vitro cytotoxicity testing of mixtures of reactants [{Fe(salen)}2(mý-O)] and HL, as well as the respective reactants, was also performed. It has been found that the cytotoxicity of 5 and 6 against all the tested cell lines is probably caused by a combined effect of the individual components presented within the corresponding mixture in the medium used
dcterms:title
Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines
skos:prefLabel
Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines
skos:notation
RIV/61989592:15310/12:33142501!RIV13-MSM-15310___
n11:predkladatel
n18:orjk%3A15310
n4:aktivita
n9:P n9:Z
n4:aktivity
P(ED2.1.00/03.0058), P(EE2.3.20.0017), P(GBP303/12/G163), Z(MSM6198959218)
n4:cisloPeriodika
3
n4:dodaniDat
n13:2013
n4:domaciTvurceVysledku
n7:2321459 n7:3214915 n7:8069239 n7:1000462
n4:druhVysledku
n6:J
n4:duvernostUdaju
n22:S
n4:entitaPredkladatele
n21:predkladatel
n4:idSjednocenehoVysledku
135116
n4:idVysledku
RIV/61989592:15310/12:33142501
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Uv-Vis spectroscopy; In vitro cytotoxicity; Salen; Iron(III) complexes
n4:klicoveSlovo
n14:In%20vitro%20cytotoxicity n14:Salen n14:Uv-Vis%20spectroscopy n14:Iron%28III%29%20complexes
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[B72C0CD27CAF]
n4:nazevZdroje
Toxicology in Vitro
n4:obor
n19:CA
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n5:GBP303%2F12%2FG163 n5:ED2.1.00%2F03.0058 n5:EE2.3.20.0017
n4:rokUplatneniVysledku
n13:2012
n4:svazekPeriodika
26
n4:tvurceVysledku
Štarha, Pavel Dvořák, Zdeněk Trávníček, Zdeněk Šindelář, Zdeněk
n4:wos
000302455500013
n4:zamer
n15:MSM6198959218
s:issn
0887-2333
s:numberOfPages
5
n10:doi
10.1016/j.tiv.2012.01.006
n20:organizacniJednotka
15310