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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F12%3A33142414%21RIV13-GA0-15310___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0308814612001896
dcterms:description
Berberine is a constituent of many traditional herbal remedies. However, its anti-inflammatory effect is still unclear and it probably involves multiple mechanisms. Several years ago, we demonstrated that berberine is an activator of aryl hydrocarbon receptor (AhR) in human and rodent hepatoma cell lines (Vrzal et al., 2005). We described an induction of CYP1A1 mRNA and protein, nuclear translocation of AhR-GFP chimeric construct and trans-activation of xenobiotic-responsive element in gene reporter assays, upon treatment with berberine. For this reason, we propose here an involvement of AhR in the in vivo effects of berberine, described in paper by Chueh and Lin. Berberine is a constituent of many traditional herbal remedies. However, its anti-inflammatory effect is still unclear and it probably involves multiple mechanisms. Several years ago, we demonstrated that berberine is an activator of aryl hydrocarbon receptor (AhR) in human and rodent hepatoma cell lines (Vrzal et al., 2005). We described an induction of CYP1A1 mRNA and protein, nuclear translocation of AhR-GFP chimeric construct and trans-activation of xenobiotic-responsive element in gene reporter assays, upon treatment with berberine. For this reason, we propose here an involvement of AhR in the in vivo effects of berberine, described in paper by Chueh and Lin.
dcterms:title
A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine
skos:prefLabel
A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine
skos:notation
RIV/61989592:15310/12:33142414!RIV13-GA0-15310___
n11:predkladatel
n18:orjk%3A15310
n5:aktivita
n20:P
n5:aktivity
P(GBP303/12/G163)
n5:cisloPeriodika
4
n5:dodaniDat
n14:2013
n5:domaciTvurceVysledku
n12:8069239 n12:4908171
n5:druhVysledku
n19:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
120494
n5:idVysledku
RIV/61989592:15310/12:33142414
n5:jazykVysledku
n21:eng
n5:klicovaSlova
induction; activation; cells; aryl-hydrocarbon receptor
n5:klicoveSlovo
n6:aryl-hydrocarbon%20receptor n6:activation n6:cells n6:induction
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[E52239AAC4FC]
n5:nazevZdroje
Food Chemistry
n5:obor
n16:FR
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
2
n5:projekt
n15:GBP303%2F12%2FG163
n5:rokUplatneniVysledku
n14:2012
n5:svazekPeriodika
133
n5:tvurceVysledku
Vrzal, Radim Dvořák, Zdeněk
n5:wos
000303847400077
s:issn
0308-8146
s:numberOfPages
2
n9:doi
10.1016/j.foodchem.2012.02.024
n13:organizacniJednotka
15310