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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F12%3A33142297%21RIV13-MSM-15310___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Endogenous neuropeptides, acting as neurotransmitters or hormones in the brain, carry out important functions including neural plasticity, metabolism and angiogenesis. Previous neuropeptide studies have focused on peptide-rich brain regions such as the striatum or hypothalamus. Here we present an investigation of peptides in the visual system, composed of brain regions that are generally less rich in peptides, with the aim of providing the first broad overview of peptides involved in mammalian visual functions. We target three important parts of the visual system: the primary visual cortex (V1), lateral geniculate nucleus (LGN) and superior colliculus (SC). Our study is performed in the tree shrew, a close relative of primates. Using a combination of data dependent acquisition and targeted LC-MS/MS based neuropeptidomics; we identified a total of 52 peptides from the tree shrew visual system. A total of 26 peptides, for example GAV and neuropeptide K were identified in the visual system for the first time. Out of the total 52 peptides, 27 peptides with high signal-to-noise-ratio (}10) in extracted ion chromatograms (EIC) were subjected to label-free quantitation. We observed generally lower abundance of peptides in the LGN compared to V1 and SC. Consistently, a number of individual peptides showed high abundance in V1 (such as neuropeptide Y or somatostatin 28) and in SC (such as somatostatin 28 AA1-12). This study provides the first in-depth characterization of peptides in the mammalian visual system. These findings now permit the investigation of neuropeptide-regulated mechanisms of visual perception. Endogenous neuropeptides, acting as neurotransmitters or hormones in the brain, carry out important functions including neural plasticity, metabolism and angiogenesis. Previous neuropeptide studies have focused on peptide-rich brain regions such as the striatum or hypothalamus. Here we present an investigation of peptides in the visual system, composed of brain regions that are generally less rich in peptides, with the aim of providing the first broad overview of peptides involved in mammalian visual functions. We target three important parts of the visual system: the primary visual cortex (V1), lateral geniculate nucleus (LGN) and superior colliculus (SC). Our study is performed in the tree shrew, a close relative of primates. Using a combination of data dependent acquisition and targeted LC-MS/MS based neuropeptidomics; we identified a total of 52 peptides from the tree shrew visual system. A total of 26 peptides, for example GAV and neuropeptide K were identified in the visual system for the first time. Out of the total 52 peptides, 27 peptides with high signal-to-noise-ratio (}10) in extracted ion chromatograms (EIC) were subjected to label-free quantitation. We observed generally lower abundance of peptides in the LGN compared to V1 and SC. Consistently, a number of individual peptides showed high abundance in V1 (such as neuropeptide Y or somatostatin 28) and in SC (such as somatostatin 28 AA1-12). This study provides the first in-depth characterization of peptides in the mammalian visual system. These findings now permit the investigation of neuropeptide-regulated mechanisms of visual perception.
dcterms:title
Broad characterization of endogenous peptides in the tree shrew visual system Broad characterization of endogenous peptides in the tree shrew visual system
skos:prefLabel
Broad characterization of endogenous peptides in the tree shrew visual system Broad characterization of endogenous peptides in the tree shrew visual system
skos:notation
RIV/61989592:15310/12:33142297!RIV13-MSM-15310___
n4:predkladatel
n20:orjk%3A15310
n5:aktivita
n14:Z
n5:aktivity
Z(MSM6198959216)
n5:cisloPeriodika
9
n5:dodaniDat
n7:2013
n5:domaciTvurceVysledku
n19:6833446
n5:druhVysledku
n8:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
125558
n5:idVysledku
RIV/61989592:15310/12:33142297
n5:jazykVysledku
n11:eng
n5:klicovaSlova
Mass spectrometry; Tupaia belangeri; Visual system; Neuropeptides
n5:klicoveSlovo
n12:Mass%20spectrometry n12:Visual%20system n12:Tupaia%20belangeri n12:Neuropeptides
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[BF34C8807CB8]
n5:nazevZdroje
Journal of Proteomics
n5:obor
n10:CE
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
6
n5:rokUplatneniVysledku
n7:2012
n5:svazekPeriodika
75
n5:tvurceVysledku
Ranc, Václav Zhang, Xiaozhe Argandona, Enrike G. Petruziello, Filomena Kretz, Robert Rainer, Gregor
n5:wos
000304634000002
n5:zamer
n13:MSM6198959216
s:issn
1874-3919
s:numberOfPages
10
n18:doi
10.1016/j.jprot.2012.01.028
n3:organizacniJednotka
15310