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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F11%3A33118318%21RIV12-MSM-15310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
A number of 5-alkoxymethyluracil analogues were synthesized in order to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukemia cells and solid tumor derived cell lines. In addition to this, the cytotoxic activity of 5-alkoxymethyluracil analogues 1,2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3,4. Extensive structure-cytotoxic activity relationship studies are reported. A number of 5-alkoxymethyluracil analogues were synthesized in order to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukemia cells and solid tumor derived cell lines. In addition to this, the cytotoxic activity of 5-alkoxymethyluracil analogues 1,2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3,4. Extensive structure-cytotoxic activity relationship studies are reported.
dcterms:title
Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study
skos:prefLabel
Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study
skos:notation
RIV/61989592:15310/11:33118318!RIV12-MSM-15310___
n12:predkladatel
n19:orjk%3A15310
n3:aktivita
n4:P n4:Z
n3:aktivity
P(ED0030/01/01), Z(MSM6198959216), Z(MSM6198959223)
n3:cisloPeriodika
14
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n11:5110386 n11:9546006
n3:druhVysledku
n20:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
233924
n3:idVysledku
RIV/61989592:15310/11:33118318
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Nucleosides, Alkoxymethyluracils, Alkoxymethyluridines, Cytotoxic activity
n3:klicoveSlovo
n8:Alkoxymethyluracils n8:Alkoxymethyluridines n8:Nucleosides n8:Cytotoxic%20activity
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[84BCDFDC6798]
n3:nazevZdroje
Carbohydrate Research
n3:obor
n17:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n21:ED0030%2F01%2F01
n3:rokUplatneniVysledku
n16:2011
n3:svazekPeriodika
346
n3:tvurceVysledku
Hajdúch, Marián Brulíková, Lucie Džubák, Petr Hlaváč, Jan
n3:wos
000295754100011
n3:zamer
n5:MSM6198959223 n5:MSM6198959216
s:issn
0008-6215
s:numberOfPages
9
n18:doi
10.1016/j.carres.2011.07.026
n14:organizacniJednotka
15310