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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F11%3A33118219%21RIV12-MSM-15310___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Two types of magnetic binary nanocomposites, Ag@Fe3O4 and g-Fe2O3@Ag, were synthesized and characterized and their antibacterial activities were tested. As a magnetic component, Fe3O4 (magnetite) nanoparticles with an average size of about 70 nm and monodisperse g-Fe2O3(maghemite) nanoparticles with an average size of 5 nm were used. Nanocomposites were prepared via in situ chemical reduction of silver ions by maltose in the presence of particular magnetic phase and molecules of polyacrylate serving as a spacer among iron oxide and silver nanoparticles. In the case of the Ag@Fe3O4 nanocomposite, silver nanoparticles, caught at the surfaces of Fe3O4nanocrystals, were around 5 nm in a size. On the contrary, in the case of the g-Fe2O3@Ag nanocomposite, ultrafine g-Fe2O3 nanoparticles surrounded silver nanoparticles ranging in a size between 20 and 40 nm. In addition, the molecules of polyacrylate in this nanocomposite type suppress considerably interparticle magnetic interactions as proved by magnetization measurements. Both synthesized nanocomposites exhibited very significant antibacterial and antifungal activities against ten tested bacterial strains (minimum inhibition concentrations (MIC) from 15.6 mg/L to 125 mg/L) and four candida species (MIC from 1.9 mg/L to 31.3 mg/L). Moreover, acute nanocomposite cytotoxicity against mice embryonal fibroblasts was observed at concentrations of higher than 430 mg/L (Ag@Fe3O4) and 292 mg/L (g-Fe2O3@Ag). With respect to the non-cytotoxic nature of the polyacrylate linker, both kinds of silver nanocomposites arewell applicable for a targeted magnetic delivery of silver nanoparticles in medicinal and disinfection applications. Two types of magnetic binary nanocomposites, Ag@Fe3O4 and g-Fe2O3@Ag, were synthesized and characterized and their antibacterial activities were tested. As a magnetic component, Fe3O4 (magnetite) nanoparticles with an average size of about 70 nm and monodisperse g-Fe2O3(maghemite) nanoparticles with an average size of 5 nm were used. Nanocomposites were prepared via in situ chemical reduction of silver ions by maltose in the presence of particular magnetic phase and molecules of polyacrylate serving as a spacer among iron oxide and silver nanoparticles. In the case of the Ag@Fe3O4 nanocomposite, silver nanoparticles, caught at the surfaces of Fe3O4nanocrystals, were around 5 nm in a size. On the contrary, in the case of the g-Fe2O3@Ag nanocomposite, ultrafine g-Fe2O3 nanoparticles surrounded silver nanoparticles ranging in a size between 20 and 40 nm. In addition, the molecules of polyacrylate in this nanocomposite type suppress considerably interparticle magnetic interactions as proved by magnetization measurements. Both synthesized nanocomposites exhibited very significant antibacterial and antifungal activities against ten tested bacterial strains (minimum inhibition concentrations (MIC) from 15.6 mg/L to 125 mg/L) and four candida species (MIC from 1.9 mg/L to 31.3 mg/L). Moreover, acute nanocomposite cytotoxicity against mice embryonal fibroblasts was observed at concentrations of higher than 430 mg/L (Ag@Fe3O4) and 292 mg/L (g-Fe2O3@Ag). With respect to the non-cytotoxic nature of the polyacrylate linker, both kinds of silver nanocomposites arewell applicable for a targeted magnetic delivery of silver nanoparticles in medicinal and disinfection applications.
dcterms:title
The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles
skos:prefLabel
The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles
skos:notation
RIV/61989592:15310/11:33118219!RIV12-MSM-15310___
n7:predkladatel
n8:orjk%3A15310
n4:aktivita
n5:Z n5:P
n4:aktivity
P(1M0512), P(ED0030/01/01), P(ED2.1.00/03.0058), P(GAP304/10/1316), P(KAN115600801), Z(MSM6198959218), Z(MSM6198959223)
n4:cisloPeriodika
21
n4:dodaniDat
n13:2012
n4:domaciTvurceVysledku
n11:5892961 n11:9251189 n11:7621175 n11:1448870 n11:1733028 n11:7321023 n11:5207193
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
234213
n4:idVysledku
RIV/61989592:15310/11:33118219
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Nanocomposite, nanoparticles, silver, magnetism, iron oxides, antimicrobial agent, cytotoxicity.
n4:klicoveSlovo
n10:silver n10:magnetism n10:cytotoxicity. n10:nanoparticles n10:antimicrobial%20agent n10:iron%20oxides n10:Nanocomposite
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[56EA0A4B656F]
n4:nazevZdroje
Biomaterials
n4:obor
n15:JJ
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
9
n4:projekt
n9:1M0512 n9:KAN115600801 n9:GAP304%2F10%2F1316 n9:ED0030%2F01%2F01 n9:ED2.1.00%2F03.0058
n4:rokUplatneniVysledku
n13:2011
n4:svazekPeriodika
32
n4:tvurceVysledku
Kilianová, Martina Kvítek, Libor Tománková, Kateřina Zbořil, Radek Filip, Jan Tuček, Jiří Kolář, Milan Panáček, Aleš Prucek, Robert
n4:wos
000291571400003
n4:zamer
n18:MSM6198959218 n18:MSM6198959223
s:issn
0142-9612
s:numberOfPages
10
n21:doi
10.1016/j.biomaterials.2011.03.039
n20:organizacniJednotka
15310