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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F11%3A33116860%21RIV12-MSM-15310___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
A series of mixed-ligand complexes [Cu(qui)(L)]NO3.xH2O (1-6), where Hqui = 2-phenyl-3-hydroxy-4(1H)-quinolinone, L = 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), bis(2-pyridyl)amine (ambpy) (3), 5-methyl-1,10-phenanthroline (mphen) (4), 5-nitro-1,10-phenanthroline (nphen) (5) and bathophenanthroline (bphen) (6), have been synthesized and fully characterized. The X-ray structures of [Cu(qui)(phen)]NO3.H2O (2) and [Cu(qui)(ambpy)]NO3 (3a) show a slightly distorted square-planar geometry in the vicinity of the central copper(II) atom. An in vitro cytotoxicity study of the complexes found significant activity against human osteosarcoma (HOS) and human breast adenocarcinoma (MCF7) cell lines, with the best results for complex 6, where IC50 equals 2.1 +/- 0.2 uM, and 2.2 +/- 0.4 uM, respectively. The strong interactions of the complexes with calf thymus DNA (CT-DNA) and high ability to cleave pUC19 DNA plasmid were found. A series of mixed-ligand complexes [Cu(qui)(L)]NO3.xH2O (1-6), where Hqui = 2-phenyl-3-hydroxy-4(1H)-quinolinone, L = 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), bis(2-pyridyl)amine (ambpy) (3), 5-methyl-1,10-phenanthroline (mphen) (4), 5-nitro-1,10-phenanthroline (nphen) (5) and bathophenanthroline (bphen) (6), have been synthesized and fully characterized. The X-ray structures of [Cu(qui)(phen)]NO3.H2O (2) and [Cu(qui)(ambpy)]NO3 (3a) show a slightly distorted square-planar geometry in the vicinity of the central copper(II) atom. An in vitro cytotoxicity study of the complexes found significant activity against human osteosarcoma (HOS) and human breast adenocarcinoma (MCF7) cell lines, with the best results for complex 6, where IC50 equals 2.1 +/- 0.2 uM, and 2.2 +/- 0.4 uM, respectively. The strong interactions of the complexes with calf thymus DNA (CT-DNA) and high ability to cleave pUC19 DNA plasmid were found.
dcterms:title
Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone
skos:prefLabel
Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone
skos:notation
RIV/61989592:15310/11:33116860!RIV12-MSM-15310___
n12:predkladatel
n18:orjk%3A15310
n3:aktivita
n8:P n8:Z
n3:aktivity
P(ED2.1.00/03.0058), P(EE2.3.20.0017), P(GAP207/11/0841), Z(MSM6198959218)
n3:cisloPeriodika
37
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n7:8069239 n7:6407226 n7:4192478 n7:2321459 n7:6683266
n3:druhVysledku
n4:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
233894
n3:idVysledku
RIV/61989592:15310/11:33116860
n3:jazykVysledku
n21:eng
n3:klicovaSlova
Copper(II), 2-phenyl-3-hydroxy-4(1H)-quinolinone, In vitro cytotoxicity, DNA interaction, DNA cleavage
n3:klicoveSlovo
n17:DNA%20cleavage n17:Copper%28II%29 n17:In%20vitro%20cytotoxicity n17:DNA%20interaction n17:2-phenyl-3-hydroxy-4%281H%29-quinolinone
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[06876E13BBC7]
n3:nazevZdroje
Dalton Transactions (print)
n3:obor
n19:CA
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n5:ED2.1.00%2F03.0058 n5:GAP207%2F11%2F0841 n5:EE2.3.20.0017
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
40
n3:tvurceVysledku
Herchel, Radovan Vančo, Ján Buchtík, Roman Trávníček, Zdeněk Dvořák, Zdeněk
n3:wos
000294666700010
n3:zamer
n11:MSM6198959218
s:issn
1477-9226
s:numberOfPages
9
n16:doi
10.1039/c1dt10674k
n14:organizacniJednotka
15310