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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F10%3A10216567%21RIV11-MSM-15310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
In vitro antitumour activity of the [Pt(ox)(L-n)(2)] (1-7) and [Pd(ox)(L-n)(2)] (8-14) oxalato (ox) complexes involving N6-benzyl-9-isopropyladenine-based N-donor carrier ligands (L-n) against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis), malignant melanoma (G-361), lung carcinoma (A549), cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was studied. Some of the tested complexes were even several times more cytotoxic as compared with cisplatin employed as a positive control. In vitro antitumour activity of the [Pt(ox)(L-n)(2)] (1-7) and [Pd(ox)(L-n)(2)] (8-14) oxalato (ox) complexes involving N6-benzyl-9-isopropyladenine-based N-donor carrier ligands (L-n) against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis), malignant melanoma (G-361), lung carcinoma (A549), cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was studied. Some of the tested complexes were even several times more cytotoxic as compared with cisplatin employed as a positive control.
dcterms:title
Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands
skos:prefLabel
Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands
skos:notation
RIV/61989592:15310/10:10216567!RIV11-MSM-15310___
n3:aktivita
n12:S n12:Z
n3:aktivity
S, Z(MSM6198959218)
n3:cisloPeriodika
10
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n7:4908171 n7:2321459 n7:8069239 n7:3214915
n3:druhVysledku
n11:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
257854
n3:idVysledku
RIV/61989592:15310/10:10216567
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Human hepatocytes; In vitro cytotoxicity; Oxalato complexes; Palladium(II); Platinum(II)
n3:klicoveSlovo
n4:Oxalato%20complexes n4:Palladium%28II%29 n4:Platinum%28II%29 n4:Human%20hepatocytes n4:In%20vitro%20cytotoxicity
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[272491668B01]
n3:nazevZdroje
Journal of Inorganic Biochemistry
n3:obor
n17:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
104
n3:tvurceVysledku
Vrzal, Radim Dvořák, Zdeněk Trávníček, Zdeněk Štarha, Pavel
n3:wos
000281525200017
n3:zamer
n10:MSM6198959218
s:issn
0162-0134
s:numberOfPages
3
n18:organizacniJednotka
15310