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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F10%3A10215688%21RIV11-MSM-15310___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
A rapid procedure based on direct extraction and RP-HPLC separation of pregabalin and its possible impurities with fluorescence detection has been developed. The separation conditions and parameters of derivatization reaction for postcolumn derivatization of pregabalin with o-phtaldialdehyde/2-mercaptoethanol were studied. Purospher STAR RP-8e column with isocratic elution was employed Fluorescence detection was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively The proposed method has an advantage of a simple sample pre-treatment and a quick and very sensitive HPLC method. The applicability of developed method was successfully verified during analysis of commercial samples of tablets of Lyrica (Pfizer, USA). A rapid procedure based on direct extraction and RP-HPLC separation of pregabalin and its possible impurities with fluorescence detection has been developed. The separation conditions and parameters of derivatization reaction for postcolumn derivatization of pregabalin with o-phtaldialdehyde/2-mercaptoethanol were studied. Purospher STAR RP-8e column with isocratic elution was employed Fluorescence detection was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively The proposed method has an advantage of a simple sample pre-treatment and a quick and very sensitive HPLC method. The applicability of developed method was successfully verified during analysis of commercial samples of tablets of Lyrica (Pfizer, USA).
dcterms:title
Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde
skos:prefLabel
Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde
skos:notation
RIV/61989592:15310/10:10215688!RIV11-MSM-15310___
n3:aktivita
n10:Z
n3:aktivity
Z(MSM6198959216)
n3:cisloPeriodika
3
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n15:4316851
n3:druhVysledku
n6:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
268619
n3:idVysledku
RIV/61989592:15310/10:10215688
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Postcolumn derivatization; Phamaceutical formulation; Validation; Pregabalin; Reversed-phase separation; HPLC
n3:klicoveSlovo
n7:HPLC n7:Reversed-phase%20separation n7:Postcolumn%20derivatization n7:Validation n7:Phamaceutical%20formulation n7:Pregabalin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[603C26D27B58]
n3:nazevZdroje
Journal of Pharmaceutical and Biomedical Analysis
n3:obor
n17:CB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
53
n3:tvurceVysledku
Gibala, Petr Douša, Michal Lemr, Karel
n3:wos
000280435800067
n3:zamer
n18:MSM6198959216
s:issn
0731-7085
s:numberOfPages
6
n9:organizacniJednotka
15310