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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F10%3A10212153%21RIV11-GA0-15310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
A series of dinuclear copper(II) complexes of the compositions [Cu2(mi-Ln)2(mi-Cl)2Cl2] (1, 2), [Cu2-(mi-Ln)4Cl2]Cl2.2H2O (3, 4) and [Cu2(mi-Ln)4(ClO4)2](ClO4)2.xSolv (5, 6; xSolv = 4MeOH for 5 and 2EtOH for 6), involving 6-(benzylamino)purine derivatives (Ln), have been evaluated with the aim to determine their possible drug interactions and their capability to induce the expression of major drug-metabolizing cytochromes P450. A series of dinuclear copper(II) complexes of the compositions [Cu2(mi-Ln)2(mi-Cl)2Cl2] (1, 2), [Cu2-(mi-Ln)4Cl2]Cl2.2H2O (3, 4) and [Cu2(mi-Ln)4(ClO4)2](ClO4)2.xSolv (5, 6; xSolv = 4MeOH for 5 and 2EtOH for 6), involving 6-(benzylamino)purine derivatives (Ln), have been evaluated with the aim to determine their possible drug interactions and their capability to induce the expression of major drug-metabolizing cytochromes P450.
dcterms:title
Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes
skos:prefLabel
Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes
skos:notation
RIV/61989592:15310/10:10212153!RIV11-GA0-15310___
n4:aktivita
n16:Z n16:P
n4:aktivity
P(GA303/07/0128), P(GP305/08/P089), Z(MSM6198959218)
n4:cisloPeriodika
6
n4:dodaniDat
n13:2011
n4:domaciTvurceVysledku
n9:3694704 n9:8069239 n9:4908171 n9:3214915 n9:2321459
n4:druhVysledku
n18:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
256301
n4:idVysledku
RIV/61989592:15310/10:10212153
n4:jazykVysledku
n6:eng
n4:klicovaSlova
Human hepatocytes, cytochrome P450, dinuclear copper(II) complexes, gene induction
n4:klicoveSlovo
n5:gene%20induction n5:cytochrome%20P450 n5:Human%20hepatocytes n5:dinuclear%20copper%28II%29%20complexes
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[CA0D97C98B34]
n4:nazevZdroje
Toxicology in Vitro
n4:obor
n14:EB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n19:GA303%2F07%2F0128 n19:GP305%2F08%2FP089
n4:rokUplatneniVysledku
n13:2010
n4:svazekPeriodika
25
n4:tvurceVysledku
TRÁVNÍČEK, Zdeněk Dvořák, Zdeněk VRZAL, Radim ŠTARHA, Pavel KLANICOVÁ, Alena
n4:wos
000275991700011
n4:zamer
n7:MSM6198959218
s:issn
0887-2333
s:numberOfPages
5
n11:organizacniJednotka
15310