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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F09%3A10214125%21RIV11-MSM-15310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones. 2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
dcterms:title
3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds 3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds
skos:prefLabel
3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds 3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds
skos:notation
RIV/61989592:15310/09:10214125!RIV11-MSM-15310___
n3:aktivita
n4:P n4:Z n4:S
n3:aktivity
P(LC07017), S, Z(MSM6198959216), Z(MSM6198959223)
n3:cisloPeriodika
6
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n5:1759256 n5:8225583 n5:5110386
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
353927
n3:idVysledku
RIV/61989592:15310/09:10214125
n3:jazykVysledku
n12:eng
n3:klicovaSlova
2-Phenyl-3-hydroxy-4(1H)-quinolinones
n3:klicoveSlovo
n9:2-Phenyl-3-hydroxy-4%281H%29-quinolinones
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[8ADA9415CD7C]
n3:nazevZdroje
Mini Reviews in Medicinal Chemistry
n3:obor
n16:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n15:LC07017
n3:rokUplatneniVysledku
n14:2009
n3:svazekPeriodika
9
n3:tvurceVysledku
Večeřová, Renata Hradil, Pavel Kolář, Milan Soural, Miroslav Hlaváč, Jan Hajdúch, Marián
n3:wos
000267047200006
n3:zamer
n8:MSM6198959216 n8:MSM6198959223
s:issn
1389-5575
s:numberOfPages
7
n18:organizacniJednotka
15310