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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F09%3A00010414%21RIV10-MSM-15310___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively. A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively.
dcterms:title
Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant
skos:prefLabel
Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant
skos:notation
RIV/61989592:15310/09:00010414!RIV10-MSM-15310___
n3:aktivita
n10:S n10:P n10:Z
n3:aktivity
P(GP203/07/P223), S, Z(MSM6198959216)
n3:cisloPeriodika
20
n3:dodaniDat
n9:2010
n3:domaciTvurceVysledku
n4:6267408 n4:2670003 Znaleziona, Joanna n4:2098628 n4:2465205 n4:6670784
n3:druhVysledku
n5:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
309877
n3:idVysledku
RIV/61989592:15310/09:00010414
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Micellar electrokinetic chromatography; Antihyperglycemic drug; Antidiabetic drug; Gliclazide; Glibenclamide; Glimepiride; Glipizide; Repaglinide; Tolbutamide; Non-ionic surfactant; Genapol X-080; Triton X-114 (reduced); On-line preconcentration
n3:klicoveSlovo
n11:On-line%20preconcentration n11:Non-ionic%20surfactant n11:Triton%20X-114%20%28reduced%29 n11:Antihyperglycemic%20drug n11:Antidiabetic%20drug n11:Glimepiride n11:Genapol%20X-080 n11:Glipizide n11:Repaglinide n11:Glibenclamide n11:Gliclazide n11:Tolbutamide n11:Micellar%20electrokinetic%20chromatography
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[53306B245F9B]
n3:nazevZdroje
Journal of Chromatography A: Symposium Volumes
n3:obor
n18:CB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n16:GP203%2F07%2FP223
n3:rokUplatneniVysledku
n9:2009
n3:svazekPeriodika
1216
n3:tvurceVysledku
Znaleziona, Joanna Maier, Vítězslav Jirovský, David Ševčík, Juraj Petr, Jan Skopalová, Jana
n3:zamer
n15:MSM6198959216
s:issn
0021-9673
s:numberOfPages
7
n12:organizacniJednotka
15310