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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F09%3A00010358%21RIV10-MSM-15310___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of numerous procarcinogens, carcinogens, environmental toxicants, or therapeutic agents. Several endogenous factors, including hormones, can modify CYP1A induction, directly influencing CYP1A gene expression or AhR function or indirectly via crosstalks with other transcription factors. In this article, we summarize the current knowledge about the role of hormones (i.e., glucocorticoids, estrogens, progesterone, androgens, insulin, and glucagon) and hormone receptors as well as other essential factors (e.g., vitamin D, retinoids) in the modulation of CYP1A expression. Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of numerous procarcinogens, carcinogens, environmental toxicants, or therapeutic agents. Several endogenous factors, including hormones, can modify CYP1A induction, directly influencing CYP1A gene expression or AhR function or indirectly via crosstalks with other transcription factors. In this article, we summarize the current knowledge about the role of hormones (i.e., glucocorticoids, estrogens, progesterone, androgens, insulin, and glucagon) and hormone receptors as well as other essential factors (e.g., vitamin D, retinoids) in the modulation of CYP1A expression.
dcterms:title
Hormonal regulation of CYP1A expression. Hormonal regulation of CYP1A expression.
skos:prefLabel
Hormonal regulation of CYP1A expression. Hormonal regulation of CYP1A expression.
skos:notation
RIV/61989592:15310/09:00010358!RIV10-MSM-15310___
n3:aktivita
n9:S
n3:aktivity
S
n3:cisloPeriodika
4
n3:dodaniDat
n10:2010
n3:domaciTvurceVysledku
n15:8069239
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
317765
n3:idVysledku
RIV/61989592:15310/09:00010358
n3:jazykVysledku
n16:eng
n3:klicovaSlova
CYP1A; hormonal regulation
n3:klicoveSlovo
n8:hormonal%20regulation n8:CYP1A
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E1B20E8D1116]
n3:nazevZdroje
Drug Metabolism Reviews
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
41
n3:tvurceVysledku
Monostory, Katalin Pascussi, Jean-Marc Kóbori, László Dvořák, Zdeněk
s:issn
0360-2532
s:numberOfPages
26
n11:organizacniJednotka
15310