This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n19http://localhost/temp/predkladatel/
n9http://linked.opendata.cz/resource/domain/vavai/projekt/
n7http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n18http://linked.opendata.cz/ontology/domain/vavai/
n12http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n17http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61989592%3A15310%2F08%3A00005427%21RIV10-MSM-15310___/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n16http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F08%3A00005427%21RIV10-MSM-15310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all. analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 mu L samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been dem A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all. analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 mu L samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been dem
dcterms:title
Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples
skos:prefLabel
Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples
skos:notation
RIV/61989592:15310/08:00005427!RIV10-MSM-15310___
n3:aktivita
n10:S n10:P n10:Z
n3:aktivity
P(GA203/07/0765), S, Z(MSM6198959216)
n3:cisloPeriodika
6
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n7:4316851 n7:8390924 n7:4140702 n7:6833446
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
381594
n3:idVysledku
RIV/61989592:15310/08:00005427
n3:jazykVysledku
n4:eng
n3:klicovaSlova
nano-desorption electrospray; mass spectrometry; kinetic method; chiral analysis; drug analysis; human blood samples
n3:klicoveSlovo
n13:human%20blood%20samples n13:mass%20spectrometry n13:kinetic%20method n13:drug%20analysis n13:nano-desorption%20electrospray n13:chiral%20analysis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2087044EC651]
n3:nazevZdroje
European Journal of Mass Spectrometry
n3:obor
n14:CB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n9:GA203%2F07%2F0765
n3:rokUplatneniVysledku
n16:2008
n3:svazekPeriodika
14
n3:tvurceVysledku
Ranc, Václav Lemr, Karel Havlíček, Vladimír Bednář, Petr
n3:zamer
n12:MSM6198959216
s:issn
1469-0667
s:numberOfPages
7
n19:organizacniJednotka
15310