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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F06%3A00003049%21RIV10-MSM-15310___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The subchronic safety of sanguiritrin, a mixture of sanguinarine ( SA) and chelerythrine (CHE) quaternary benzo[c] phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin ( 100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2% of QBA were absorbed through the GIT while 98% were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a P-32-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, live The subchronic safety of sanguiritrin, a mixture of sanguinarine ( SA) and chelerythrine (CHE) quaternary benzo[c] phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin ( 100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2% of QBA were absorbed through the GIT while 98% were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a P-32-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, live
dcterms:title
Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats
skos:prefLabel
Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats
skos:notation
RIV/61989592:15310/06:00003049!RIV10-MSM-15310___
n3:aktivita
n7:Z n7:P
n3:aktivity
P(GP203/03/D237), Z(MSM6198959216)
n3:cisloPeriodika
4
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n4:8321124 n4:5773458 n4:6670784 n4:2326868 n4:2514559 n4:8419647 n4:2706571 n4:7925662 n4:8341362 n4:3540693 n4:8738394
n3:druhVysledku
n18:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
498353
n3:idVysledku
RIV/61989592:15310/06:00003049
n3:jazykVysledku
n17:eng
n3:klicovaSlova
benzo[c]phenanthridine alkaloids; oral administration; biochemical markers; oxidative stress; DNA damage; cytochrome P450
n3:klicoveSlovo
n6:DNA%20damage n6:oral%20administration n6:oxidative%20stress n6:benzo%5Bc%5Dphenanthridine%20alkaloids n6:cytochrome%20P450 n6:biochemical%20markers
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3D732B7471BE]
n3:nazevZdroje
Veterinární medicína
n3:obor
n5:CE
n3:pocetDomacichTvurcuVysledku
11
n3:pocetTvurcuVysledku
13
n3:projekt
n15:GP203%2F03%2FD237
n3:rokUplatneniVysledku
n16:2006
n3:svazekPeriodika
51
n3:tvurceVysledku
Vičar, Jaroslav Anzenbacherová, Eva Kosina, Pavel Svobodová, Alena Hrbáč, Jan Zdařilová, Adéla Jirovský, David Psotová, Jitka Stiborová, M. Lichnovský, Václav Šimánek, Vilím Ulrichová, Jitka Večeřa, Rostislav
n3:zamer
n10:MSM6198959216
s:issn
0375-8427
s:numberOfPages
11
n13:organizacniJednotka
15310