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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F04%3A00002278%21RIV%2F2005%2FGA0%2F153105%2FN
rdf:type
skos:Concept n20:Vysledek
dcterms:description
New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivatives exhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named %22olomoucine%22 (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the G1/S and G2/M New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivatives exhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named %22olomoucine%22 (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the G1/S and G2/M Jsou popsány nové deriváty cytokininů pro zemědělství a medicínu.
dcterms:title
New cytokinin derivatives for agriculture and medicine New cytokinin derivatives for agriculture and medicine Nové deriváty cytokininů pro zemědělství a medicínu
skos:prefLabel
New cytokinin derivatives for agriculture and medicine Nové deriváty cytokininů pro zemědělství a medicínu New cytokinin derivatives for agriculture and medicine
skos:notation
RIV/61989592:15310/04:00002278!RIV/2005/GA0/153105/N
n4:strany
76
n4:aktivita
n12:Z n12:P
n4:aktivity
P(GA522/01/0275), Z(MSM 153100008)
n4:dodaniDat
n10:2005
n4:domaciTvurceVysledku
n11:9961216 n11:4712048 n11:6282520 n11:5991803 n11:8905428 n11:9896821
n4:druhVysledku
n16:D
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
576056
n4:idVysledku
RIV/61989592:15310/04:00002278
n4:jazykVysledku
n18:eng
n4:klicovaSlova
Cytokinin;6-benzylaminopurine;olomoucine;bohemine;roscovitine;antitumour effects
n4:klicoveSlovo
n6:roscovitine n6:olomoucine n6:Cytokinin n6:bohemine n6:6-benzylaminopurine n6:antitumour%20effects
n4:kontrolniKodProRIV
[FAB0F7A1668D]
n4:mistoVydani
Canberra
n4:nazevZdroje
18th IPGSA conference, Conference Handbook
n4:obor
n8:EF
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
8
n4:projekt
n14:GA522%2F01%2F0275
n4:rokUplatneniVysledku
n10:2004
n4:tvurceVysledku
Doležal, Karel Lenobel, René Binarová, Pavla Kryštof, Vladimír Havlíček, Libor Popa, Igor Strnad, Miroslav Zatloukal, Marek
n4:zamer
n17:MSM%20153100008
s:numberOfPages
144
n15:hasPublisher
Australian National University
n13:organizacniJednotka
15310