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Statements

Subject Item
n2:RIV%2F61989592%3A15310%2F02%3A00001425%21RIV%2F2003%2FMSM%2F153103%2FN
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Recent highlights in understanding molecular nature of signaling pathways that mediate biological effects of various external stimuli and control number of normal physiological processes of cells such as growth, differentiation, senescence and apoptosis,defined three major groups of proteins which apparently play an essential role in transmitting external signals from surface membrane to target genes in the nucleus. These include Janus kinases (JAKs), signal transducers and activators of transcription (STATs) and their endogenous inhibitors of SOCS family. Their inappropriate functioning and defective cross-talking associate with several human disorders including cancer. There is an increasing evidence that perturbances in STAT proteins are involved in the pathogenesis of some human malignancies. Moreover, cancer-related defective JAK/STAT/SOCS pathways may negatively affect tumor response to the cytokine-based immunotherapy. This article provides an overview of the current knowledge about JAK/STAT/S Recent highlights in understanding molecular nature of signaling pathways that mediate biological effects of various external stimuli and control number of normal physiological processes of cells such as growth, differentiation, senescence and apoptosis,defined three major groups of proteins which apparently play an essential role in transmitting external signals from surface membrane to target genes in the nucleus. These include Janus kinases (JAKs), signal transducers and activators of transcription (STATs) and their endogenous inhibitors of SOCS family. Their inappropriate functioning and defective cross-talking associate with several human disorders including cancer. There is an increasing evidence that perturbances in STAT proteins are involved in the pathogenesis of some human malignancies. Moreover, cancer-related defective JAK/STAT/SOCS pathways may negatively affect tumor response to the cytokine-based immunotherapy. This article provides an overview of the current knowledge about JAK/STAT/S
dcterms:title
JAK/STAT signaling pathways and cancer JAK/STAT signaling pathways and cancer
skos:prefLabel
JAK/STAT signaling pathways and cancer JAK/STAT signaling pathways and cancer
skos:notation
RIV/61989592:15310/02:00001425!RIV/2003/MSM/153103/N
n3:strany
349-355
n3:aktivita
n13:Z
n3:aktivity
Z(MSM 153100008)
n3:cisloPeriodika
6
n3:dodaniDat
n10:2003
n3:domaciTvurceVysledku
n6:3251993
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
649969
n3:idVysledku
RIV/61989592:15310/02:00001425
n3:jazykVysledku
n8:eng
n3:klicovaSlova
STATs; SOCS; signal transduction; cancer; interferons
n3:klicoveSlovo
n5:interferons n5:signal%20transduction n5:cancer n5:STATs n5:SOCS
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[D7AFA9598CD7]
n3:nazevZdroje
Neoplasma
n3:obor
n18:EF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n10:2002
n3:svazekPeriodika
49
n3:tvurceVysledku
Boudný, Vladimír Kovařík, Jan
n3:zamer
n15:MSM%20153100008
s:issn
0028-2685
s:numberOfPages
7
n14:organizacniJednotka
15310