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Statements

Subject Item
n2:RIV%2F61989592%3A15120%2F13%3A33149368%21RIV15-MSM-15120___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://circ.ahajournals.org/content/127/19/1980.full
dcterms:description
Onset-to-reperfusion time has been reported to be associated with clinical prognosis. However, its impact on mortality remained to be assessed. Using a collaborative pooled analysis, we examined whether early mortality after successful endovascular treatment is time dependent. In a collaborative pooled analysis of 7 endovascular databases, we assessed the impact of onset-to-reperfusion time in large-artery occlusion (internal carotid artery or middle cerebral artery) on outcomes. Successful reperfusion was defined as complete or partial restoration of blood flow within 8 hours from symptom onset. Primary outcome was 90-day all-cause mortality. Secondary outcomes included 90-day favorable outcome (modified Rankin Scale score, 0-2), 90-day excellent outcome (modified Rankin Scale score, 0-1), and occurrence of any intracerebral hemorrhage within 24 to 36 hours after treatment. A total of 480 cases with successful reperfusion (median time, 285 minutes) contributed to the present pooled analysis (120 with internal carotid artery occlusion and 360 with isolated middle cerebral artery occlusion). Increasing onset-to-reperfusion time was associated with an increased rate of mortality and intracerebral hemorrhage and with a decreased rate of favorable and excellent outcomes, without heterogeneity across studies. The adjusted odds ratio for each 30-minute time increase was 1.21 (95% confidence interval, 1.09-1.34; P{0.001) for mortality, 0.79 (95% confidence interval, 0.72-0.87) for favorable outcome, 0.78 (95% confidence interval, 0.71-0.86) for excellent outcome, and 1.21 (95% confidence interval, 1.10-1.33) for intracerebral hemorrhage. Onset-to-reperfusion time affects mortality and favorable outcome and should be considered the main goal in acute stroke patient management. Onset-to-reperfusion time has been reported to be associated with clinical prognosis. However, its impact on mortality remained to be assessed. Using a collaborative pooled analysis, we examined whether early mortality after successful endovascular treatment is time dependent. In a collaborative pooled analysis of 7 endovascular databases, we assessed the impact of onset-to-reperfusion time in large-artery occlusion (internal carotid artery or middle cerebral artery) on outcomes. Successful reperfusion was defined as complete or partial restoration of blood flow within 8 hours from symptom onset. Primary outcome was 90-day all-cause mortality. Secondary outcomes included 90-day favorable outcome (modified Rankin Scale score, 0-2), 90-day excellent outcome (modified Rankin Scale score, 0-1), and occurrence of any intracerebral hemorrhage within 24 to 36 hours after treatment. A total of 480 cases with successful reperfusion (median time, 285 minutes) contributed to the present pooled analysis (120 with internal carotid artery occlusion and 360 with isolated middle cerebral artery occlusion). Increasing onset-to-reperfusion time was associated with an increased rate of mortality and intracerebral hemorrhage and with a decreased rate of favorable and excellent outcomes, without heterogeneity across studies. The adjusted odds ratio for each 30-minute time increase was 1.21 (95% confidence interval, 1.09-1.34; P{0.001) for mortality, 0.79 (95% confidence interval, 0.72-0.87) for favorable outcome, 0.78 (95% confidence interval, 0.71-0.86) for excellent outcome, and 1.21 (95% confidence interval, 1.10-1.33) for intracerebral hemorrhage. Onset-to-reperfusion time affects mortality and favorable outcome and should be considered the main goal in acute stroke patient management.
dcterms:title
Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis
skos:prefLabel
Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis
skos:notation
RIV/61989592:15120/13:33149368!RIV15-MSM-15120___
n3:aktivita
n14:S n14:N
n3:aktivity
N, S
n3:cisloPeriodika
19
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n11:3054691
n3:druhVysledku
n17:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
79017
n3:idVysledku
RIV/61989592:15120/13:33149368
n3:jazykVysledku
n12:eng
n3:klicovaSlova
stroke; stroke reperfusion injury; meta-analysis
n3:klicoveSlovo
n7:meta-analysis n7:stroke%20reperfusion%20injury n7:stroke
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[88EEBEC5E1B7]
n3:nazevZdroje
Circulation
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
14
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
127
n3:tvurceVysledku
Školoudík, David Mazighi, Makael Siddiqui, Adnan Labreuche, Julien Qureshi, Adnan Khatri, Pooja Molina, Carlos Broderick, Joseph Mokin, Maxim Meseguer, Elena Yeatts, Sharon Ribo, Marc Chaudhry, Saqib Amarenco, Pierre
n3:wos
000318970200013
s:issn
0009-7322
s:numberOfPages
6
n6:doi
10.1161/CIRCULATIONAHA.112.000311
n10:organizacniJednotka
15120